{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:53:41Z","timestamp":1772052821472,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the surgical success after trabeculotomy for primary congenital glaucoma (PCG) in Denmark in the last 40\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of medical files on children who all underwent trabeculotomy as the first surgical intervention between January 1rst, 1977 and December 31, 2016. Information on diagnosis and surgical procedures were extracted. Primary outcome was surgical success was defined as intraocular pressure (IOP)\u00a0&lt;\u00a021\u00a0mmHg without medications one year after surgery. Secondary outcome was the number of reoperations needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 118 children with PCG, 96 children (144 eyes) had an ab externo trabeculotomy as primary IOP lowering procedure opening Schlemm\u2019s channel 4 clock hours into the anterior chamber. Complete surgical success at one year was achieved in 73% (106 of 144 eyes). On the long term, IOP could be controlled by one surgical procedure in 2\/3 of children, eight eyes required &gt;5 surgical procedures to control IOP. In 12.1% of children the second glaucoma procedure was performed &gt;5\u00a0years after the initial trabeculotomy. There was a tendency towards greater risk of needing a second procedure in patients\u00a0&lt;\u00a03\u00a0months of age at primary trabeculotomy (hazard ratio, HR, 2.01, 95% CI 0.96\u20134.22) and in boys (HR 2.02, 95% CI 0.97\u20134.18) and a lower risk of requiring a third surgery if the second surgery was trabeculectomy with MMC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dedicated follow\u2010up of patients with PCG is essential as the disease may continue to progress even after years of quiescence and some children need multiple surgeries to control IOP. Additional glaucoma procedures are required in 1\/3 of children and boys and younger patients seem to be at greater risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14619","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T21:12:36Z","timestamp":1601327556000},"page":"362-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term success after trabeculotomy in primary congenital glaucoma \u2013 a study with up to 35 years follow\u2010up"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-1510","authenticated-orcid":false,"given":"Line","family":"Kessel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital of Copenhagen Rigshospitalet\u2010Glostrup Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-4074","authenticated-orcid":false,"given":"Karen Bjerg","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Copenhagen Rigshospitalet\u2010Glostrup Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkert","family":"Siersma","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice and Section of General Practice Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-3318","authenticated-orcid":false,"given":"Per","family":"Kappelgaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Copenhagen Rigshospitalet\u2010Glostrup Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-5104","authenticated-orcid":false,"given":"Daniella","family":"Bach\u2010Holm","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Copenhagen Rigshospitalet\u2010Glostrup Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.047761"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.32.9.701"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.12.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(60)91007-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2019.05.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-EGSguideline.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176386"},{"key":"e_1_2_6_10_1","first-page":"CD008213","article-title":"Surgical interventions for primary congenital glaucoma","volume":"1","author":"Ghate D","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306269"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118805872"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13018"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02954372"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000067"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-017-0506-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14207"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/393670"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.08.022"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.11.025"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-322X.156120"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000182"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000516"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702223"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000784"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14619","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T16:51:09Z","timestamp":1693414269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/aos.14619"],"URL":"https:\/\/doi.org\/10.1111\/aos.14619","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"2020-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}