{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:04:38Z","timestamp":1788959078005,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To demonstrate through the use of optical coherence tomography angiography (OCTA) that normal vasoreactivity cannot be monitored in central serous chorioretinopathy (CSR) patients in the presence of vasoactive stimuli owing to hypoxia caused by the breath\u2010holding manoeuvre (BHM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included a total of 210 eyes, including 70 CSR patients (70 symptomatic eyes, 70 asymptomatic eyes) and 70 control group. Images of the macula (3\u00a0\u00d7\u00a03\u00a0mm) and the optic disc (4.5\u00a0\u00d7\u00a04.5\u00a0mm) were obtained at the baseline and after BHM using OCTA. The change in vascular parameters in the OCTA after BHM was evaluated in CSR patients and the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the symptomatic eyes of CSR patients, the mean whole image vessel density (VD) in the superficial capillary plexus decreased from 48.0\u00a0\u00b1\u00a03.5% under baseline conditions to 46.0\u00a0\u00b1\u00a04.5% after BHM (p\u00a0&lt;\u00a00.01), and the mean whole VD in the deep capillary plexus decreased from 47.9\u00a0\u00b1\u00a08.0% under baseline conditions to 46.9\u00a0\u00b1\u00a06.7% after BHM (p\u00a0&lt;\u00a00.01). The OCTA after BHM revealed a decrease in the mean whole image VD of the optic disc in both symptomatic (50.4\u00a0\u00b1\u00a02.1% to 49.6\u00a0\u00b1\u00a02.0%, p\u00a0&lt;\u00a00.05) and asymptomatic (50.9\u00a0\u00b1\u00a01.8% to 50.4\u00a0\u00b1\u00a01.9%, p\u00a0&lt;\u00a00.05) eyes of CSR patients. No difference for any mean VD of the control group was seen between the baseline and after BHM. Outer retinal flow areas increased significantly after BHM compared with the baseline in both eyes of CSR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that CSR pathogenesis is related to an imbalance in local vascular regulation and the sympathetic activity of the autonomic nervous system. This technique constitutes a new way of studying retinal vascular changes and may be applied to CSR patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14625","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:21:30Z","timestamp":1601468490000},"page":"787-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optical coherence tomography angiography of central serous chorioretinopathy patients\u2019 response to breath\u2010holding manoeuvre"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-6887","authenticated-orcid":false,"given":"Murat","family":"Karapapak","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Basaksehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Department of 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