{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:32:24Z","timestamp":1778578344005,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy of XEN<jats:sup>\u00ae<\/jats:sup> Gel Stent implantation in the treatment of primary open\u2010angle glaucoma (POAG) and pseudoexfoliation glaucoma (XFG) regarding the reduction of intraocular pressure (IOP) and number of IOP\u2010lowering medications over 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective, observational, single\u2010centre study, patients with POAG or XFG underwent implantation of the XEN<jats:sup>\u00ae<\/jats:sup> Gel Stent with or without combined phacoemulsification. Changes in mean IOP, mean number of IOP\u2010lowering medications, number of postoperative interventions, complete or qualified surgical success rate (defined as IOP\u00a0&lt;\u00a018\u00a0mmHg without or with IOP\u2010lowering medication, respectively) and complete surgical failure rate (defined as the necessity of a glaucoma\u2010related secondary surgical intervention or loss of light perception) were assessed 12\u00a0months (12M) and 24\u00a0months (24M) postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010nine eyes of 63 patients with open\u2010angle glaucoma were included in the study (71% POAG, 29% XFG). Before surgery, mean IOP was 23.4\u00a0\u00b1\u00a07.9\u00a0mmHg. IOP was 14.6\u00a0\u00b1\u00a03.6\u00a0mmHg 12\u00a0months postoperatively (\u221231% from baseline, 95% CI \u221242% to \u221220%, <jats:italic>n<\/jats:italic>\u00a0=\u00a030, p\u00a0&lt;\u00a00.001) and 14.8\u00a0\u00b1\u00a04.4\u00a0mmHg 24\u00a0months postoperatively (\u221229% from baseline, 95% CI \u221230% to \u221241%, <jats:italic>n<\/jats:italic>\u00a0=\u00a028, p\u00a0&lt;\u00a00.001). Mean number of IOP\u2010lowering medications was significantly reduced from 2.7\u00a0\u00b1\u00a01.1 before surgery to 1.0\u00a0\u00b1\u00a01.2 (\u221269%, 95% CI \u221289% to 46%, p\u00a0&lt;\u00a00.001) 12\u00a0months after surgery and 1.0\u00a0\u00b1\u00a01.2 (\u221264%, 95% CI \u221291% to \u221236%, p\u00a0&lt;\u00a00.001) at 24\u00a0months after surgery. Complete surgical success was achieved in 39% (12M) and 34% (24M) of patients and qualified success in 29% (12M) and 27% (24M). 13 (16%) eyes were classified as complete surgical failure. In 62% of the patients needling procedures had to be performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The XEN<jats:sup>\u00ae<\/jats:sup> Gel Stent is an efficacious minimal invasive glaucoma surgery for primary open\u2010angle and pseudoexfoliation glaucoma, resulting in significant reduction of IOP and a reduction in glaucoma medications from baseline in two\u2010third of treated patients with 2\u2010year follow\u2010up. Frequent follow\u2010up examinations were mandatory to identify early and late bleb failure and additional needling procedures were necessary to reestablish aqueous flow.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14627","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:08:16Z","timestamp":1601467696000},"page":"369-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Two\u2010year outcomes of minimally invasive XEN Gel Stent implantation in primary open\u2010angle and pseudoexfoliation glaucoma"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-6333","authenticated-orcid":false,"given":"Teresa","family":"Rauchegger","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry Medical University of Innsbruck Innsbruck 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