{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:24Z","timestamp":1787013864452,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess differences in the progression of macular atrophy (MA) between neovascular age\u2010related macular degeneration (AMD) subtypes and to identify the risk factors associated with the foveal involvement among patients with MA undergoing long\u2010term anti\u2010vascular endothelial growth factor (VEGF) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty eyes of 80 patients with neovascular AMD who developed incident MA following anti\u2010VEGF therapy were retrospectively included. Macular atrophy (MA) was quantified using autofluoresence (AF) images within 24\u00a0months after the onset of MA, and the enlargement rate was compared between neovascular AMD subtypes. Regression models were constructed to explore relationships between foveal involvement in MA and baseline characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The growth rate of MA was 0.18\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year for type 1 neovascularization (NV), 0.24\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year for type 2 NV, and 1.21\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year for type 3 NV; differences between groups were significant (p\u00a0=\u00a00.022). Multivariate logistic regression analysis revealed that thin subfoveal choroidal thickness (p\u00a0=\u00a00.028), presence of subretinal drusenoid deposit (p\u00a0=\u00a00.005), type 2 or 3 NV (p\u00a0=\u00a00.023), and geographic atrophy in the fellow eye (p\u00a0=\u00a00.035) were significant risk factors for MA with foveal involvement. The number of injections showed no significant association with the progression or the foveal involvement in MA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The progression of MA in patients with neovascular AMD undergoing anti\u2010VEGF treatment differed significantly depending on the subtype of neovascularization. The risk of foveal involvement in MA was associated with the baseline factors or phenotype of neovascular AMD rather than with injection frequency of anti\u2010VEGF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14631","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T07:50:22Z","timestamp":1601452222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Progression of macular atrophy in patients undergoing anti\u2010vascular endothelial growth factor therapy for neovascular age\u2010related macular degeneration"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-5762","authenticated-orcid":false,"given":"Han Joo","family":"Cho","sequence":"first","affiliation":[{"name":"Kim's Eye Hospital, Konyang University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang 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