{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:37:40Z","timestamp":1775673460573,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009399","name":"Macular Disease Foundation Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine the prevalence and risk factors for depressive symptoms in patients with neovascular age\u2010related macular degeneration (nAMD) presenting for anti\u2010vascular endothelial growth factor (anti\u2010VEGF) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a clinic\u2010based cohort of 547 patients with nAMD who presented for treatment, the Centre of Epidemiological Studies Depression 10\u2010point scale (CES\u2010D\u201010) and Mental Health Index (MHI) component of the 36\u2010item Short Form Survey were administered to assess for the presence of depressive symptoms. Logistic regression analyses were used to calculate odds ratios and 95% confidence intervals for factors associated with an increased likelihood of depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of depressive symptoms was 42.04% and 31.78% as per the CES\u2010D\u201010 and MHI scales, respectively. Poor self\u2010rated health (SRH) is associated with increased odds of depressive symptoms [multivariable\u2010adjusted OR: 3.00 (95% CI 1.90\u20134.73) for CES\u2010D\u201010; OR: 2.67 (95% CI 1.67\u20134.28) for MHI]. Impaired activities of daily living (ADLs) [multivariable\u2010adjusted OR: 2.62 (95% CI 1.56\u20134.38) for CES\u2010D\u201010; OR: 3.59 (95% CI 2.10\u20136.15) for MHI] and a visual function score within the two lowest quartiles were also associated with increased odds of depressive symptoms using both scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high prevalence of depressive symptoms was observed among nAMD patients presenting for treatment. Poorer SRH, ADL impairment and reduced visual function were associated with increased odds of depressive symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14635","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T15:02:55Z","timestamp":1601218975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and risk factors for depressive symptoms in patients with neovascular age\u2010related macular degeneration who present for anti\u2010VEGF therapy"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-0303","authenticated-orcid":false,"given":"Kim Van","family":"Vu","sequence":"first","affiliation":[{"name":"Centre for Vision Research The Westmead Institute for Medical Research The University of Sydney Sydney 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