{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:19:39Z","timestamp":1783577979567,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To present a case series of a modified three\u2010quarter Descemet\u2019s membrane endothelial keratoplasty (3\/4\u2010DMEK) technique to treat pseudophakic bullous keratopathy in the presence of a glaucoma drainage device (GDD) tube in the anterior chamber by reducing the risk of donor endothelial damage due to absence of donor endothelial cells overlying the GGD tube area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective case series, four eyes of three patients with stable glaucoma underwent 3\/4\u2010DMEK surgery for pseudophakic bullous keratopathy after GDD insertion. The patients were followed up to 24\u00a0\u00b1\u00a02.5\u00a0months postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No intraoperative or postoperative complications were noted. The average central endothelial cell density (ECD) was 1093\u00a0\u00b1\u00a074\u00a0cells\/mm<jats:sup>2<\/jats:sup> at 12\u00a0months postoperatively, corresponding to an ECD decrease of 58 (\u00b16)% as compared to preoperative values. Average best\u2010corrected visual acuity increased from finger counting before surgery to 20\/60 (logMar 0.5) at 12\u00a0months after 3\/4\u2010DMEK and remained stable up to 24\u00a0months postoperatively. All corneas remained clear at the last available follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case series demonstrates the technical feasibility of 3\/4\u2010DMEK in eyes with pseudophakic bullous keratopathy in the presence of a GDD tube. The absence of a donor DM and donor cells above the silicone tube excludes direct tube contact with the graft. Longer term studies are needed to show the effect of this modified graft pattern and dimensions on transplant survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14645","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T06:15:17Z","timestamp":1604038517000},"page":"569-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Three\u2010quarter DMEK in eyes with glaucoma draining devices to avoid secondary graft failure"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3081-2101","authenticated-orcid":false,"given":"Oganes","family":"Oganesyan","sequence":"first","affiliation":[{"name":"The Helmholtz Moscow Institute of Eye Diseases Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Makarov","sequence":"additional","affiliation":[{"name":"The Helmholtz Moscow Institute of Eye Diseases Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Grdikanyan","sequence":"additional","affiliation":[{"name":"The Helmholtz Moscow Institute of Eye Diseases Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Oganesyan","sequence":"additional","affiliation":[{"name":"The Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vostan","family":"Getadaryan","sequence":"additional","affiliation":[{"name":"The Helmholtz Moscow Institute of Eye Diseases Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit R. 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