{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T18:37:34Z","timestamp":1771699054169,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare subfoveal choroidal thickness (SFCT) and associated clinical variables in patients with carotid stenosis (CS) before and 6\u00a0months after carotid endarterectomy (CEA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective non\u2010randomized Helsinki Carotid Endarterectomy Study \u2013 Brain and Eye Sub\u2010sTudy included seventy patients (81% male, mean age 69\u00a0years) and 40 control subjects (77% male, 68\u00a0years), from March 2015 to December 2018. Ophthalmological examination included SFCT measured with enhanced\u2010depth imaging\u2010optical coherence tomography. Carotid stenosis (CS) was more severe (\u226570% stenosis in 92%) ipsilateral to the CEA than contralaterally (&lt;50% stenosis in 74%; p\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, patients had thinner mean SFCT than control subjects in both eyes (ipsilateral, 222 versus 257\u00a0<jats:italic>\u03bc<\/jats:italic>m and contralateral, 217 versus 258\u00a0<jats:italic>\u03bc<\/jats:italic>m, p\u00a0\u2264\u00a00.005). At follow\u2010up, SFCT did not change in ipsi\u2010 and contralateral eyes compared to baseline in patients (p\u00a0=\u00a00.68 and p\u00a0=\u00a00.77), or in control subjects (p\u00a0=\u00a00.59 and p\u00a0=\u00a00.79). Patients with coronary artery disease had thinner mean SFCT versus those without it in ipsilateral eyes before CEA (200 versus 233\u00a0<jats:italic>\u03bc<\/jats:italic>m, p\u00a0=\u00a00.027). In ipsilateral eyes of patients before CEA, thinner SFCT and ocular signs of CS, plaque and hypoperfusion related findings combined, were associated (p\u00a0=\u00a00.036), and the best\u2010corrected visual acuity, measured in logMAR, increased with increasing SFCT (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.25; p\u00a0=\u00a00.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subfoveal choroidal thickness (SFCT) is thinner in patients with CS without association between SFCT and the grade of CS. Unchanged SFCT after CEA suggests, that choroidal vessels in severe CS are unable to react to increased blood flow. Bilaterally thin SFCT could be considered as yet another sign of CS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14648","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T13:23:55Z","timestamp":1608816235000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Subfoveal choroidal thickness in ipsi\u2010 and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-5493","authenticated-orcid":false,"given":"Marianne","family":"Ala\u2010Kauhaluoma","sequence":"first","affiliation":[{"name":"Ophthalmology Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvi M.","family":"Koskinen","sequence":"additional","affiliation":[{"name":"HUS 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Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Ij\u00e4s","sequence":"additional","affiliation":[{"name":"Neurology Clinical Neurosciences Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Relander","sequence":"additional","affiliation":[{"name":"Neuropsychology Clinical Neurosciences Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perttu J.","family":"Lindsberg","sequence":"additional","affiliation":[{"name":"Neurology Clinical Neurosciences Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauri","family":"Soinne","sequence":"additional","affiliation":[{"name":"Neurology Clinical Neurosciences Helsinki University Hospital and University of Helsinki Helsinki 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