{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:04:40Z","timestamp":1775012680529,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010378","name":"Stichting Wetenschappelijk Onderzoek Oogziekenhuis","doi-asserted-by":"publisher","award":["2018S04"],"award-info":[{"award-number":["2018S04"]}],"id":[{"id":"10.13039\/501100010378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010372","name":"Rotterdamse Stichting Blindenbelangen","doi-asserted-by":"publisher","award":["B20180055"],"award-info":[{"award-number":["B20180055"]}],"id":[{"id":"10.13039\/501100010372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Perifoveal exudative vascular anomalous complex (PEVAC) was initially described as an isolated aneurysmal lesion in healthy eyes. Similar aneurysmal abnormalities may occur in association with retinal vascular diseases such as diabetic retinopathy or retinal vein occlusions (PEVAC\u2010resembling). The aim of this study was to compare several imaging characteristics of PEVAC and PEVAC\u2010resembling lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten eyes with a PEVAC and 27 eyes with a PEVAC\u2010resembling lesion were included in this cross\u2010sectional study. They were all imaged with optical coherence tomography (OCT), OCT angiography (OCT\u2010A) and colour fundus photography (CFP). Several clinical, morphological and vascular characteristics were assessed and compared between both PEVAC types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All PEVAC lesions were unilateral, while PEVAC\u2010resembling lesions appeared bilateral in 23% of patients (p\u00a0&gt;\u00a00.05). Unilateral multifocal PEVAC\u2010resembling lesions were more frequently observed (56%) than unilateral multifocal PEVAC lesions (10%, p\u00a0&lt;\u00a00.01). Furthermore, 90% of the PEVAC lesions were located within 500\u00a0\u00b5m from the centre of the fovea, while this was only true for 56% of the PEVAC\u2010resembling lesions (p\u00a0&gt;\u00a00.05). No notable differences were observed in other studied characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical, morphological and vascular features of PEVAC and PEVAC\u2010resembling lesions are similar based on multimodal imaging. Given the bilaterality and multifocality seen in PEVAC\u2010resembling lesions, an underlying retinal vascular disease may stimulate the quantity of aneurysmal abnormalities. Due to the similarities with PEVAC\u2010resembling lesions, PEVAC may also be considered a microangiopathy but with an unknown origin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14650","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:47:57Z","timestamp":1605822477000},"page":"553-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Multimodal imaging comparison of perifoveal exudative vascular anomalous complex and resembling lesions"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0400-7579","authenticated-orcid":false,"given":"Lisette M.","family":"Smid","sequence":"first","affiliation":[{"name":"Rotterdam Ophthalmic Institute Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-9804","authenticated-orcid":false,"given":"Jennifer S. N.","family":"Verhoekx","sequence":"additional","affiliation":[{"name":"Medical Retina Service Rotterdam Eye Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P.","family":"Martinez Ciriano","sequence":"additional","affiliation":[{"name":"Medical Retina Service Rotterdam Eye Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koenraad A.","family":"Vermeer","sequence":"additional","affiliation":[{"name":"Rotterdam Ophthalmic Institute Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Yzer","sequence":"additional","affiliation":[{"name":"Medical Retina Service Rotterdam Eye Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000182903.16652.d7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.35.4.189"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.010"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990022"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1175-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100717"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.6.1.10427"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.06.015"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.8.3.60"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","unstructured":"KernTS&HuangS(2010):Ocular disease: mechanisms and management.506\u2013513.","DOI":"10.1016\/B978-0-7020-2983-7.00065-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2019.1626450"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002435"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2011.03.002"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.10.009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002406"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.79.4.362"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12868"},{"key":"e_1_2_5_19_1","article-title":"Anatomical changes on sequential multimodal imaging in perifoveal exudative vascular anomalous complex","author":"Verhoekx JSN","year":"2020","journal-title":"Retina"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","unstructured":"WileyHE&FerrisFL(2013):Nonproliferative diabetic retinopathy and diabetic macular edema.940\u2013968.","DOI":"10.1016\/B978-1-4557-0737-9.00047-3"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14650","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:59:10Z","timestamp":1693342750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/aos.14650"],"URL":"https:\/\/doi.org\/10.1111\/aos.14650","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"assertion":[{"value":"2020-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}