{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:17:35Z","timestamp":1790965055026,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A3B03031470"],"award-info":[{"award-number":["2017R1D1A3B03031470"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A5A2025272"],"award-info":[{"award-number":["2018R1A5A2025272"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acupuncture is a treatment option for dry eye syndrome (DES), but its efficacy remains still controversial. We assessed the effectiveness of this treatment for typical DES without specific aetiologies. Eight databases up through June 2018 were searched for randomized clinical trials (RCTs) comparing treatments of acupuncture with artificial tears. The risk of bias was assessed using Cochrane criteria, and a random effects model was used for meta\u2010analyses on tear\u2010film breakup time (BUT), Schirmer test, corneal fluorescein staining (CFS), ocular surface disease index, visual analogue scale and score of symptoms (SOS). Subgroup and sensitivity analyses were conducted to explore the heterogeneity, and publication bias was assessed by funnel plot using Egger\u2019s test. Twenty\u2010one RCTs in 19 studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a01542 eyes) met our eligible criteria. The results demonstrated the superiority of acupuncture in improving the symptoms of BUT, Schirmer test, CFS and SOS, compared to artificial tears acting alone. The BUT and Schirmer test were also more improved in acupuncture combination with artificial tears than artificial tears alone. Further subgroup analyses suggest that acupuncture applied at 2.0\u20133.0 times per week for 21\u201330\u00a0days may be optimal for treating typical DES. This provides useful information for guiding acupuncture in the clinical trials.<\/jats:p>","DOI":"10.1111\/aos.14651","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T05:51:56Z","timestamp":1604037116000},"page":"489-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Therapeutic effects of acupuncture in typical dry eye: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"99","author":[{"given":"Ji\u2010Ho","family":"Na","sequence":"first","affiliation":[{"name":"College of Korean Medicine Daegu Haany University Gyeongsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hyeo","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Daegu Haany University Gyeongsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon\u2010Gon","family":"Park","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Daegu Haany University Gyeongsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-258X","authenticated-orcid":false,"given":"Phil Hyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine Yeungnam University Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-462X","authenticated-orcid":false,"given":"Chang\u2010Hyun","family":"Song","sequence":"additional","affiliation":[{"name":"College of Korean Medicine Daegu Haany University Gyeongsan Korea"},{"name":"Department of Anatomy and Histology College of Korean Medicine Daegu Haany University Gyeongsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2013.0968"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.83653"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.011"},{"key":"e_1_2_5_5_1","first-page":"1","volume-title":"The clinical observations on efficacy of a qi\u2014absorption needling technique in treating dry eye syndromes (Thesis for Master's degree)","author":"Chao Y","year":"2016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.135319"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70083-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S175321"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_5_11_1","first-page":"1594","article-title":"Clinical observation on acupuncture treatment of dry eye syndrome","volume":"38","author":"Feng J","year":"2017","journal-title":"Shaanxi J Tradit Chin Med"},{"key":"e_1_2_5_12_1","first-page":"478","article-title":"Observation on therapeutic effect of dry eye syndrome treated with acupuncture on the acupoints around the eyes","volume":"30","author":"Gao WP","year":"2010","journal-title":"Zhongguo zhen jiu= Chinese acupuncture & moxibustion"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3727\/036012907815844011"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2004.00254.x"},{"key":"e_1_2_5_15_1","first-page":"680","article-title":"Infrared thermography and meridian\u2010effect evidence and explanation in Bell's palsy patients treated by moxibustion at the Hegu (LI4) acupoint: overall regulation or a specific target?","volume":"7","author":"Guan L","year":"2012","journal-title":"Neural Regen Res"},{"key":"e_1_2_5_16_1","first-page":"CD011392","article-title":"Management strategies for pancreatic pseudocysts","volume":"4","author":"Gurusamy KS","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_17_1","first-page":"158","article-title":"Effect of acupuncture on lacrimal film of xeroma patients","volume":"20","author":"He H","year":"2004","journal-title":"J Nanjing TCM Univ"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.38"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_5_21_1","first-page":"1","volume-title":"Sodium hyaluronate eye drops treatment of lung yin deficiency clinical study of dry eye acupuncture acupoints with five (Thesis for Master's degree)","author":"Hu J","year":"2017"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2009.0537"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-017-1011-1"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1559-9"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735407305892"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2202-0"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.02.030"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036638"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006030.pub2"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01855.x"},{"key":"e_1_2_5_31_1","first-page":"53","article-title":"Clinical Observation on 26 Cases of Dry Eye Syndrome Treated with Acupuncture","volume":"16","author":"Leng XL","year":"2016","journal-title":"World Latest Med"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7300.1479"},{"key":"e_1_2_5_33_1","first-page":"27","article-title":"Observation on the therapeutic effect of periocular acupuncture on dry eye syndrome","volume":"23","author":"Li XJ","year":"2015","journal-title":"China's Naturopathy"},{"key":"e_1_2_5_34_1","first-page":"233","article-title":"Clinical Observation on Acupuncture Treatment of Dry Eye Syndrome of Liver and Kidney Yin","volume":"1","author":"Li J","year":"2016","journal-title":"J of Hunan University of Tradit Chin Med"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016359850136058"},{"key":"e_1_2_5_37_1","first-page":"235","article-title":"Effect of acupuncture combined with ultrasonic atomizing inhalation on the treatment of xerophthalmus","volume":"37","author":"Liu J","year":"2015","journal-title":"Hebei J Tradit Chin Med"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S126968"},{"key":"e_1_2_5_39_1","first-page":"714","article-title":"Observation on therapeutic effect of acupuncture for treatment of optic atrophy","volume":"29","author":"Liu Y","year":"2009","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_5_40_1","first-page":"229","article-title":"Effect of artificial tears combined with local acupuncture on tear secretion in patients with water\u2010deficient type dry eye syndrome","volume":"33","author":"Liu ZH","year":"2014","journal-title":"China Practical Med"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/aim.24.1.13"},{"key":"e_1_2_5_42_1","first-page":"165","article-title":"Clinical Study on Acupuncture Treatment of Dry Eye","volume":"34","author":"Mei L","year":"2016","journal-title":"J Sichuan Tradit Chin Med"},{"key":"e_1_2_5_43_1","first-page":"1","volume-title":"Clinical observation of 60 cases of dry eye syndrome by the treatment of eye acupuncture combining the artificial tears (Thesis for Master's degree)","author":"Nan HP","year":"2014"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0717-8_102"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2005.tb00284.x"},{"key":"e_1_2_5_46_1","first-page":"364","article-title":"Clinical efficacy on xerosis conjunctivitis of liver and kidney yin deficiency treated with SHI's acupuncture manipulation","volume":"36","author":"Ni W","year":"2016","journal-title":"Zhongguo zhen jiu"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6405471"},{"key":"e_1_2_5_48_1","first-page":"18","article-title":"The effect of acupuncture on the tear production in the patients with Sjogren syndrome","volume":"13","author":"Pang Y","year":"2003","journal-title":"J Tradit Chin Ophthalmol"},{"key":"e_1_2_5_49_1","first-page":"S102","article-title":"Prevalence, burden, and pharmacoeconomics of dry eye disease","volume":"14","author":"Pflugfelder SC","year":"2008","journal-title":"Am J Manag Care"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.601843"},{"key":"e_1_2_5_51_1","first-page":"1003","article-title":"Effects of acupuncture on lactoferrin content in tears and tear secretion in patients suffering from dry eyes","volume":"10","author":"Shi J","year":"2012","journal-title":"J Int Med"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02027.x"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000140834.30654.0F"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v11i2.35"},{"key":"e_1_2_5_55_1","first-page":"232","volume-title":"Basics of acupuncture","author":"Stux G","year":"2012"},{"key":"e_1_2_5_56_1","first-page":"195","article-title":"Effect of acupuncture at Baihui (GV 20) and Zusanli (ST 36) on the level of serum inflammatory cytokines in patients with depression","volume":"30","author":"Sun H","year":"2010","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_5_57_1","first-page":"1","volume-title":"Management of postoperative pain with acupuncture","author":"Sun P","year":"2007"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2018-000150"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0600376X"},{"key":"e_1_2_5_60_1","first-page":"49","article-title":"Acupuncture treatment of dry eye syndrome in 56 cases","volume":"38","author":"Wang J","year":"2015","journal-title":"Guangxi J Tradit Chin Med"},{"key":"e_1_2_5_61_1","first-page":"709","article-title":"Efficacy assessment of acupuncture and moxibustion on tear secretion in xerophthalmia","volume":"30","author":"Wei LX","year":"2010","journal-title":"Zhongguo zhen jiu"},{"key":"e_1_2_5_62_1","first-page":"730","article-title":"The Efficacy of Acupuncture at Phenomaxillary Ganglion and Periocular Acupiont for the Treatment of Dry Eye","volume":"40","author":"Xiang S","year":"2016","journal-title":"Journal of Zhejiang Chinese Medical University"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/143858"},{"key":"e_1_2_5_64_1","first-page":"895","article-title":"30 cases of dry eye syndrome treated by acupuncture","volume":"29","author":"Zhang C","year":"2009","journal-title":"Henan Tradit Chin Med"},{"key":"e_1_2_5_65_1","first-page":"123","article-title":"Observation on the therapeutic effect of acupuncture on dry eye syndrome in perimenopausal women","volume":"28","author":"Zhang Y","year":"2009","journal-title":"Beijing J Tradit Chin Med"},{"key":"e_1_2_5_66_1","first-page":"1195","article-title":"Therapeutic observation of hair needle therapy for dry eye syndrome","author":"Zhang D","year":"2015","journal-title":"Shanghai J Acupunct Moxibust"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.10.076737"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010924"},{"key":"e_1_2_5_69_1","first-page":"258","article-title":"Effects of acupuncture and moxibustion on tear\u2010film of the patients with xerophthalmia","volume":"27","author":"Zhang Y","year":"2007","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/429412"},{"key":"e_1_2_5_71_1","first-page":"342","article-title":"Randomized controlled study on the analgesic effect of superficial needling plus electrostimulation of sanyinjiao (SP6) for primary dysmenorrhea","volume":"32","author":"Zhi LX","year":"2007","journal-title":"Zhen Ci Yan Jiu"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:00:59Z","timestamp":1693342859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/aos.14651"],"URL":"https:\/\/doi.org\/10.1111\/aos.14651","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"2020-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}