{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:57:22Z","timestamp":1790632642584,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Glucocorticoid intake is a well\u2010established risk factor for central serous chorioretinopathy that belongs to the pachychoroid spectrum disease (PSD). The study aimed to assess the prevalence of PSD and analyse the choroidal phenotype in patients with Cushing syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was performed in Ophtalmop\u00f4le h\u00f4pital Cochin, Paris, France, with a systematic evaluation of hospitalized patients with Cushing syndrome, between November 2017 and July 2018. 56 eyes from 28 Cushing syndrome patients and 56 eyes of 28 age and gender\u2010matched, and close spherical equivalent healthy participants were included. All patients underwent a complete ophthalmic examination including Enhanced\u2010Depth Imaging (EDI)\u2010Optical Coherence Tomography (OCT). Measures of subfoveal, 1000\u00a0\u00b5m nasal and 1000\u00a0\u00b5m temporal choroidal thicknesses were realized, and the presence of choroidal pachyvessels was evaluated. Hormonal tests evaluated the corticotropic axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of eyes with PSD was significantly higher in Cushing syndrome patients as compared to controls (21.4% versus 3.6%, p\u00a0=\u00a00.004). In Cushing patients\u2019 eyes, 17.9% had a pachychoroid pigment epitheliopathy (PPE) and 3.6% had a polypoidal choroidal vasculopathy. Pachyvessels were more common in Cushing syndrome patients than in healthy subjects (71.4% versus 42.9%, p\u00a0=\u00a00.002). Mean subfoveal choroidal thickness was 331\u00a0\u00b1\u00a0110\u00a0\u00b5m in Cushing patients, with no statistical difference between the two groups. There was no correlation between choroidal thickness and urinary and salivary cortisol levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with Cushing syndrome have a higher prevalence of PDS. An ophthalmologic specialized follow\u2010up of these patients with EDI\u2010OCT could detect chorioretinal abnormalities and adapt the surveillance of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14664","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T05:56:09Z","timestamp":1605506169000},"page":"533-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Choroidal imaging in patients with Cushing syndrome"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1346-693X","authenticated-orcid":false,"given":"Pauline","family":"Eymard","sequence":"first","affiliation":[{"name":"Department of Ophthalmology OphtalmoP\u00f4le H\u00f4pital Cochin Assistance Publique\u2010H\u00f4pitaux de Paris AP\u2010HP Universit\u00e9 Paris 5 Sorbonne Paris Cit\u00e9 Paris 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H\u00f4pital Necker\u2010Enfants Malades AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Bertherat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology H\u00f4pital Cochin Assistance Publique H\u00f4pitaux de Paris AP\u2010HP Universit\u00e9 Paris 5 Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Behar\u2010Cohen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology OphtalmoP\u00f4le H\u00f4pital Cochin Assistance Publique\u2010H\u00f4pitaux de Paris AP\u2010HP Universit\u00e9 Paris 5 Sorbonne Paris Cit\u00e9 Paris France"},{"name":"INSERM U1138 Team 17 Centre de Recherche des Cordeliers Universit\u00e9 de Paris Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology OphtalmoP\u00f4le H\u00f4pital Cochin Assistance Publique\u2010H\u00f4pitaux de Paris AP\u2010HP Universit\u00e9 Paris 5 Sorbonne Paris Cit\u00e9 Paris France"},{"name":"INSERM U1138 Team 17 Centre de Recherche des Cordeliers Universit\u00e9 de Paris Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"154","article-title":"Choroidal and retinal abnormalities by Optical Coherence Tomography in endogenous Cushing\u2019s syndrome","volume":"9","author":"Abalem MF","year":"2016","journal-title":"Front 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