{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:41:48Z","timestamp":1758814908415,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003142","name":"Fonds NutsOhra","doi-asserted-by":"publisher","award":["122047"],"award-info":[{"award-number":["122047"]}],"id":[{"id":"10.13039\/501100003142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro\u2010aneurysms in individuals with and without type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using spectral domain optical coherence tomography (OCT), we performed a macular volume scan in 2647 individuals (mean age 60\u00a0\u00b1\u00a08\u00a0years, 50% men, 27% type 2 diabetes). The association between macular cysts and 24\u2010hour systolic and diastolic blood pressure, pulse pressure, mean arterial blood pressure, carotid\u2010femoral pulse wave velocity and carotid distensibility was assessed by use of logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four hours systolic blood pressure was associated with the presence of macular cysts [OR\u00a0=\u00a01.03 (95% CI 1.00\u20131.05) per 1\u00a0mmHg, p\u00a0=\u00a00.03]. 24\u00a0hr pulse pressure [OR\u00a0=\u00a01.61 (95% CI 1.11\u20132.34) per 10\u00a0mmHg, p\u00a0=\u00a00.01] and carotid\u2010femoral pulse wave velocity [OR\u00a0=\u00a01.16 (95% CI 1.02\u20131.32) per 1\u00a0m\/s, p\u00a0=\u00a00.02] were associated with macular cysts, while carotid distensibility was not [OR\u00a0=\u00a01.03 (95% CI 0.96\u20131.11) per 1.0*10<jats:sup>\u22123<\/jats:sup>\/kPa, p\u00a0=\u00a00.45]. Associations were similar in individuals with and without type 2 diabetes and were already present in the absence of micro\u2010aneurysms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Twenty\u2010four hours systolic blood pressure, 24\u00a0hr pulse pressure and carotid\u2010femoral pulse wave velocity are associated with the presence of OCT\u2010detected macular cysts in individuals with and without type 2 diabetes, even in the absence of micro\u2010aneurysms. Therefore, blood pressure and aortic stiffness are potential factors contributing to macular cysts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14677","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T04:27:05Z","timestamp":1606796825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vascular risk factors for optical coherence tomography\u2010detected macular cysts: The Maastricht Study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-5999","authenticated-orcid":false,"given":"Eline E. B.","family":"De Clerck","sequence":"first","affiliation":[{"name":"University Eye Clinic Maastricht Maastricht University Medical Center+ Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan S. A. 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