{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:32:09Z","timestamp":1790217129641,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Effectiveness of ocriplasmin for vitreomacular traction (VMT) varies depending on the presence of common ocular conditions and patient selection criteria. We carried out a systematic literature review and meta\u2010analysis of ocriplasmin studies conducted in real\u2010world settings (RWS) and compared outcomes with those from randomized controlled trials (RCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included prospective and retrospective studies from RWS documenting effectiveness of ocriplasmin in patients with VMT with or without MH, and RCTs of ocriplasmin versus control. Key end\u2010points were vitreomacular adhesion resolution (VMAR), nonsurgical MH closure, need for vitrectomy and safety. We conducted meta\u2010regression on pooled results to evaluate effects of baseline covariates and study design on outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty RWS (2402 patients) and 5 RCTs (737 patients) were included epiretinal membrane (ERM) and broad VMA were more prevalent in RCTs. Primary VMAR, vitrectomy and MH closure rates were comparable between RWS and RCTs. Rates of nsVMAR were significantly higher in RWS than RCTs (odds ratio 1.66; 95% confidence interval [CI]: 1.18\u20132.34). nsVMAR rates were inversely associated with ERM prevalence (odds ratio 0.20; 95% CI: 0.08\u20130.51). Compared with the recent OASIS trial, RWS reported a higher incidence of new\/worsening subretinal fluid cases and less photophobia, photopsia, vitreous floaters, electroretinogram abnormalities and MH progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ocriplasmin was significantly more effective in achieving nsVMAR in RWS than in RCTs. Lower ERM prevalence in RWS was the single significant explanatory variable for this difference. Conclusions on ocriplasmin safety in RWS are limited due to inconsistent reporting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14686","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T08:28:05Z","timestamp":1608971285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness of ocriplasmin in real\u2010world settings: A systematic literature review, meta\u2010analysis, and comparison with randomized trials"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-5599","authenticated-orcid":false,"given":"Arshad M.","family":"Khanani","sequence":"first","affiliation":[{"name":"Sierra Eye Associates Reno NV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan N.","family":"Constantine","sequence":"additional","affiliation":[{"name":"Sierra Eye Associates Reno NV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-4102","authenticated-orcid":false,"given":"Koenraad H.","family":"Blot","sequence":"additional","affiliation":[{"name":"Xintera BV Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-0330","authenticated-orcid":false,"given":"Benedicte","family":"Lescrauwaet","sequence":"additional","affiliation":[{"name":"Xintera BV Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Szurman","sequence":"additional","affiliation":[{"name":"Eye Clinic Sulzbach Knappschaft Hospital Saar Sulzbach Germany"},{"name":"Klaus Heimann Eye Research Institute (KHERI) Sulzbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2017-000110"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001536"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001432"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001785"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2015.1096941"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3031-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3363-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.06.043"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.042"},{"key":"e_1_2_5_11_1","unstructured":"European Medicines Agency(2013):EMA\/CHMP\/74766\/2013: JETREA European public assessment report. 13 Jan 2013."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.1.102"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001505"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446842"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.045"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.195"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13199"},{"key":"e_1_2_5_18_1","first-page":"29","volume-title":"Cochrane Methods","author":"Higgins JP","year":"2016"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-5-13"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.044"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3182a6b3e2"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20160808-04"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.11.022"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/192582"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.07.011"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20130715-05"},{"key":"e_1_2_5_27_1","first-page":"73","article-title":"Initial clinical experiences using ocriplasmin for the treatment of vitreomacular traction with or without a macular hole","volume":"235","author":"Lenk J","year":"2018","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2016.10.018"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3731-9"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6521304"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20150213-21"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13075"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197072"},{"key":"e_1_2_5_34_1","unstructured":"National Heart Lung and Blood Institute(2019):Study quality assessment tools: Quality assessment tool for case series studies. National Heart Lung en Blood Institute."},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000755"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-72-39"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310874"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000544"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.150"},{"key":"e_1_2_5_40_1","unstructured":"SaddaSR DugelPU GonzalezVH MeunierE&KozmaP(2017):THE OASIS MP\u20101 SUBSTUDY: characterization of the effect of ocriplasmin on microperimetry parameters. Retina Publish Ahead of Print: 1."},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001926"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.157313"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.034"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304219"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110823"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181e0970a"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.42"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16409"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002332"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-111807"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.09.015"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000507"},{"key":"e_1_2_5_53_1","first-page":"41","article-title":"Developing optimal search strategies for detecting clinically sound treatment studies in EMBASE","volume":"94","author":"Wong SS","year":"2006","journal-title":"J Med Library Assoc"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14686","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:04:09Z","timestamp":1693343049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,26]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/aos.14686"],"URL":"https:\/\/doi.org\/10.1111\/aos.14686","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,26]]},"assertion":[{"value":"2020-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}