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This paper summarizes the development of a user\u2010friendly tool that facilitates assessment of the quality of available RWE for neovascular age\u2010related macular degeneration (nAMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO). A literature search was conducted to identify tools developed to assess the quality of RWE, in order to identify the most appropriate framework on which to base this tool. The Good Research for Comparative Effectiveness (GRACE) guidelines was chosen for this purpose as it is designed to assess the quality of observational studies and has been extensively validated, including demonstration of strong sensitivity and specificity. The GRACE guidelines were adapted to develop a straightforward tabular tool that allows simple assessment and comparison of the quality of published evidence in retinal disease for researchers and physicians alike, and includes guidance on treatment details, outcome measures, study population, and controlling for bias. The newly developed tool provides a simple method to support assessment of the strength of evidence and certainty of conclusions drawn from RWE in retinal disease, to ensure clinical decision\u2010making is influenced by the highest quality evidence.<\/jats:p>","DOI":"10.1111\/aos.14698","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T17:27:22Z","timestamp":1609176442000},"page":"604-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A novel tool to assess the quality of RWE to guide the management of retinal disease"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-7597","authenticated-orcid":false,"given":"Robert P.","family":"Finger","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Daien","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Gui De Chauliac Hospital Montpellier France"},{"name":"The Save Sight Institute Sydney Medical School The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Talks","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Royal Victoria Infirmary Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Center for Vision Research Westmead Institute for Medical Research University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-1264","authenticated-orcid":false,"given":"Tien Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute Singapore National Eye Center Singapore Singapore"},{"name":"Duke\u2010NUS Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0287-3801","authenticated-orcid":false,"given":"Taiji","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima and J\u2010CREST Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bora M.","family":"Eldem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ophthalmology Department Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"L\u00f6vestam\u2010Adrian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Lund University Hospital SUS Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Korobelnik","sequence":"additional","affiliation":[{"name":"CHU Bordeaux Service d'Ophtalmologie France"},{"name":"Univ. 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