{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:25:54Z","timestamp":1783988754272,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the utility of biomechanical property measurements using a Scheimpflug\u2010based tonometer (SBT) and\/or anterior segment optical coherence tomography (AS\u2010OCT) for diagnosing forme fruste keratoconus (FFK).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective interventional case series, 23 eyes with FFK of 23 consecutive patients and 52 eyes of 52 healthy volunteers who visited our keratoconus outpatient clinic were enrolled. Logistic regression analysis was conducted to determine the causal relationship between FFK diagnosis and each parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When only SBT was used, the corneal stiffness parameter, stiffness parameter A1 (SP\u2010A1) and the corneal velocity at first applanation were selected as explanatory variables, and sensitivity, specificity and area under the receiver operating characteristic curve (AUROC) were 82.9%, 86.9% and 0.938, respectively. When only AS\u2010OCT parameters were used, the posterior corneal asymmetric component and central corneal thickness were selected, and the sensitivity, specificity and AUROC were 82.6%, 94.2% and 0.893, respectively. When parameters from both methods were used, SP\u2010A1 and the posterior corneal asymmetry component derived from Fourier analysis were selected as explanatory variables, and sensitivity, specificity and AUROC were 91.30%, 90.38% and 0.947, respectively. No significant differences in AUROC were observed between diagnoses using each device and the combination of both devices (AS\u2010OCT versus SBT, p\u00a0=\u00a00.314; integrated parameters versus AS\u2010OCT, p\u00a0=\u00a00.081; integrated parameters versus SBT, p\u00a0=\u00a00.234).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Optimization of SBT and AS\u2010OCT parameters allowed for the diagnosis of FFK at a clinically usable level. Forme fruste keratoconus (FFK) diagnosis integrating biomechanical properties with AS\u2010OCT showed no superiority compared to diagnosis based on a single device.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14700","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T04:32:16Z","timestamp":1608179536000},"page":"644-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of CorvisST biomechanical parameters and anterior segment optical coherence tomography for diagnosing forme fruste keratoconus"],"prefix":"10.1111","volume":"99","author":[{"given":"Suguru","family":"Shiga","sequence":"first","affiliation":[{"name":"Japanese Red Cross Gifu Hospital Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-0155","authenticated-orcid":false,"given":"Takashi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Gifu Hospital Gifu Japan"},{"name":"Department of Ophthalmology Keio University School of Medicine Tokyo Japan"},{"name":"Nagoya Eye Clinic Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Nishida","sequence":"additional","affiliation":[{"name":"Nagoya Eye Clinic Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Nagoya Eye Clinic Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Chukyo Eye Clinic Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.06.025"},{"key":"e_1_2_5_3_1","first-page":"842","article-title":"The\" forme fruste\" of keratoconus","volume":"73","author":"Amsler M","year":"1961","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_5_4_1","first-page":"93","volume-title":"Keratoconus\/ectasia detection with a modified (enhanced) reference surface Belin\/Ambr\u00f3sio enhanced ectasia display III. Elev Based Corneal Tomogr","author":"Belin M","year":"2012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30173-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180705-02"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303477"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180823-02"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000408"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/795738"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2016.01.009"},{"key":"e_1_2_5_14_1","first-page":"86","article-title":"Repeatability and reproducibility of corneal deformation response parameters of dynamic ultra\u2010high\u2010speed Scheimpflug imaging in keratoconus","volume":"46","author":"Herber R","year":"2020","journal-title":"J Cataract Refract Surg"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20071001-06"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-016-1283-z"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2018.10.030"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33490-z"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.147371"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20190417-01"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.02.017"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/748671"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-017-0534-9"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506839"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20151021-02"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20161221-03"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2018.1441873"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001639"},{"key":"e_1_2_5_29_1","article-title":"Repeatability and reproducibility of corneal biomechanical parameters derived from Corvis ST","author":"Serbecic N","year":"2019","journal-title":"Eur J Ophthalmol"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.031"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160629-01"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20170922-02"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20170621-09"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31372-8"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230589"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51502-4"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000628"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00740"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:02:30Z","timestamp":1693342950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/aos.14700"],"URL":"https:\/\/doi.org\/10.1111\/aos.14700","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"2020-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}