{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:32:15Z","timestamp":1788780735877,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe paediatric keratoconus (KC) patients by tomographic and aberrometric characteristics at first diagnosis, in a multicentre study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 278 eyes from 139 paediatric patients, with a first tomographic diagnosis (Pentacam<jats:sup>\u00ae<\/jats:sup>) of KC prior to 18\u00a0years old. KC classification was based on the KC Index (\u2265 1.07) and Topographic Keratoconus Classification (TKC\u00a0\u2265\u00a01). Patients were divided based on age ranges (14 and under and over 14\u00a0years) and gender. Statistical analysis was performed with SPSS statistics 25.0. ANOVA factor was carried out comparing to compare groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>278 eyes were screened, and 230 eyes were diagnosed with paediatric KC. Mean age was 15.48\u00a0\u00b1\u00a02.33 (6 to 18) years. We found differences in terms of TKC (2.08\u00a0\u00b1\u00a00.89 and 2.38\u00a0\u00b1\u00a00.82, p\u00a0&lt;\u00a00.05) and spherical aberration (\u22120.71\u00a0\u00b1\u00a00.97 and \u22121.07\u00a0\u00b1\u00a01.36, p\u00a0&lt;\u00a00.05) among the 14\u00a0years old or under and above 14\u00a0years old groups, respectively. Overall, female paediatric KC patients presented a more severe TKC, Belin Ambrosio Display, maximum keratometry, asphericity and primary and secondary coma aberrations compared to male KC patients. We observed a correlation between CDVA and asphericity (r\u00a0=\u00a00.71, p\u00a0&lt;\u00a00.01), as well as between CDVA and spherical aberration (r\u00a0=\u00a00.69, p\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings revealed that the debut of KC is usually in a moderate to advanced stage in the paediatric population at first diagnosis, particularly in female patients. Corneal tomography should be systematically performed in children with recent onset of corneal astigmatism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14715","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T21:16:12Z","timestamp":1609362972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tomographic and aberrometric assessment of first\u2010time diagnosed paediatric keratoconus based on age ranges: a multicentre study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-2493","authenticated-orcid":false,"given":"Carlos","family":"Rocha\u2010de\u2010Lossada","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Regional University Hospital of Malaga Malaga Spain"},{"name":"Department of Ophthalmology Hospital Costa del Sol Malaga Spain"},{"name":"Department of Radiology and Physical Medicine, Ophthalmology and Otorhinolaryngology, Ophthalmology Area University of Malaga Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Prieto\u2010Godoy","sequence":"additional","affiliation":[{"name":"Centre for Plant Biotechnology and Genomics Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-7717","authenticated-orcid":false,"given":"Jos\u00e9\u2010Mar\u00eda","family":"S\u00e1nchez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Physics of Condensed Matter Optics Area University of Seville Seville Spain"},{"name":"Department of Ophthalmology (Tecnolaser Clinic Vision\u00ae) Refractive Surgery Centre Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5148-7643","authenticated-orcid":false,"given":"Vito","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Royal Liverpool University Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-5647","authenticated-orcid":false,"given":"Davide","family":"Borroni","sequence":"additional","affiliation":[{"name":"Department of Doctoral Studies Riga Stradins University Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Rachwani\u2010Anil","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Regional University Hospital of Malaga Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Alba\u2010Linero","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Regional University Hospital of Malaga Malaga Spain"},{"name":"Department of Radiology and Physical Medicine, Ophthalmology and Otorhinolaryngology, Ophthalmology Area University of Malaga Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-2172","authenticated-orcid":false,"given":"Jorge","family":"Peraza\u2010Nieves","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Clinic de Barcelona Institut Clinic d'Oftalmologia Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Royal Liverpool University Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Rodr\u00edguez\u2010Calvo\u2010de\u2010Mora","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Regional University Hospital of Malaga Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.085878"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.10.046"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20060601-05"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.074955"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000164831.87593.08"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.062"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304587"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121011-01"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31825-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160513-01"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31817f815a"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.078"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.63"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2004.12.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.01.023"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000408"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002150"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.06.020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90817-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002206"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.01.025"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.06.020"},{"key":"e_1_2_6_25_1","first-page":"1","article-title":"Is Keratoconus an Inflammatory Disease? The Implication of Inflammatory Pathways","author":"Loh I\u2010P","year":"2020","journal-title":"Ocul Immunol Inflammat"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002283"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-019-0199-1"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0699-8"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-016-0382-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000537"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001975"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001102"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2016.1221978"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002054"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2009.00357.x"},{"key":"e_1_2_6_36_1","first-page":"219","article-title":"Vitesse D\u2019Evolution Du keratocone. Etude Des Relations Entre L\u2019Age De Decouverte Et L\u2019Age Auquel Il Est Opere","volume":"4","author":"Pouliquen Y","year":"1981","journal-title":"J Fr Ophtalmol"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5369"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000491"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2004.tb03155.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.020"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.036"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.03.034"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.12.049"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199603000-00006"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14715","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:02:05Z","timestamp":1693342925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/aos.14715"],"URL":"https:\/\/doi.org\/10.1111\/aos.14715","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,30]]},"assertion":[{"value":"2020-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}