{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:30:20Z","timestamp":1771047020164,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Central retinal vein occlusion (CRVO) entails retinal hypoxia that often causes visual impairment. It has been shown that oxygen saturation in larger retinal vessels correlates with the visual acuity at the time of diagnosis of CRVO but has no predictive value for the visual outcome in patients treated with anti\u2010VEGF medication after 3\u00a0months. However, assessing the predictive value of retinal oxygen saturation after 12\u00a0months is essential because this is when the main restitution after CRVO occurs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retinal oximetry was performed in 117 patients referred with CRVO to three European centres. The correlation between oxygen saturation and visual acuity at baseline and the predictive value of oxygen saturation in larger retinal vessels for the 12\u2010month visual outcome after treatment with anti\u2010VEGF medication were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the affected eye, the oxygen saturation was significantly higher in the arterioles, significantly lower in the venules, and the arterio\u2010venous (A\u2010V) significantly higher than in the unaffected eye (p\u00a0&lt;\u00a00.001 for all comparisons). Correlations between best\u2010corrected visual acuity (BCVA) and oxygen saturations were moderate and negative for arterioles (p\u00a0&lt;\u00a00.001), positive for venules (p\u00a0=\u00a00.03) and negative for the A\u2010V difference (p\u00a0=\u00a00.001). Best\u2010corrected visual acuity (BCVA), but not oxygen saturation or the other explanatory variables at baseline, contributed significantly to predicting BCVA after 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Retinal vessel oxygen saturation is affected in CRVO, and saturation correlates with BCVA. However, retinal oximetry cannot replace measures of visual function as a predictor of visual outcome after 12\u00a0months of anti\u2010VEGF treatment for CRVO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14744","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:32:21Z","timestamp":1610670741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retinal oximetry does not predict 12\u2010month visual outcome after anti\u2010VEGF treatment for central retinal vein occlusion: A multicentre study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-2631","authenticated-orcid":false,"given":"Signe","family":"Krejberg Jeppesen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-9482","authenticated-orcid":false,"given":"Martin","family":"Si\u0301n","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine and dentistry Palacky\u0301 University Olomouc Olomouc Czech Republic"},{"name":"Department of Ophthalmology Military University Hospital Prague First Faculty of Medicine Charles University Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5865-6756","authenticated-orcid":false,"given":"Sveinn","family":"Hakon Hardarson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Physiology University of Iceland Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-2534","authenticated-orcid":false,"given":"Toke","family":"Bek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital Aarhus N 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