{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:25Z","timestamp":1787013865146,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare neonatal eye screening using the red reflex test (RRT) versus the wide\u2010field digital imaging (WFDI) system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospective cohort study. Newborns (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0380, 760 eyes) in the Maternity Ward of Irmandade Santa Casa de Miserico\u0301rdia de S\u00e3o Paulo hospital from May to July 2014 underwent RRT by a paediatrician and WFDI performed by the authors. Wide\u2010field digital imaging (WFDI) images were analysed by the authors. Validity of the paediatrician\u2019s RRT was assessed by unweighted kappa [\u03ba] statistic, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While WFDI showed abnormalities in 130 eyes (17.1%), RRT was only abnormal in 13 eyes (1.7%). Wide\u2010field digital imaging (WFDI) detected treatable retina pathology that RRT missed including hyphema, CMV retinitis, FEVR and a vitreous haemorrhage. The sensitivity of the paediatrician\u2019s RRT to detect abnormalities was poor at 0.77% (95% confidence interval, CI, 0.02%\u20134.21%) with a PPV of only 7.69% (95% CI, 1.08%\u201338.85%). Overall, there was no agreement between screening modalities (\u03ba\u00a0=\u00a0\u22120.02, 95% CI, \u22120.05 to 0.01). The number needed to screen to detect ocular abnormalities using WFDI was 5.9 newborns and to detect treatable abnormalities was 76 newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While RRT detects gross abnormalities that preclude visualization of the retina (i.e. media opacities and very large tumours), only WFDI consistently detects subtle treatable retina and optic nerve pathology. With a higher sensitivity than the current gold standard, universal WFDI allows for early detection and management of potentially blinding ophthalmic disease missed by RRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14759","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T01:18:40Z","timestamp":1621905520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison between wide\u2010field digital imaging system and the red reflex test for universal newborn eye screening in Brazil"],"prefix":"10.1111","volume":"99","author":[{"given":"Laura Pires","family":"da Cunha","sequence":"first","affiliation":[{"name":"Irmandade Santa Casa de Miserico\u0301rdia de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Alexandre Agra","family":"Cavalcante 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