{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:49:56Z","timestamp":1788608996802,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine longitudinal changes of the ganglion cell\u2010inner plexiform layer (GC\u2010IPL) thickness in patients with non\u2010exudative age\u2010related macular degeneration (AMD) without other ophthalmic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010three eyes of 33 patients with early and intermediate non\u2010exudative AMD (non\u2010exudative AMD group) and 33 normal control eyes were followed for 2\u00a0years, and GC\u2010IPL thickness was measured by spectral domain optical coherence tomography at 1\u2010year intervals. The mean rate of GC\u2010IPL reduction was estimated using a linear mixed model and compared between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients in the non\u2010exudative AMD group and control groups were 68.82\u00a0\u00b1\u00a06.81\u00a0years and 67.73\u00a0\u00b1\u00a05.87\u00a0years, respectively (p\u00a0=\u00a00.488). The mean GC\u2010IPL thickness at the first visit was 76.61\u00a0\u00b1\u00a016.33\u00a0<jats:italic>\u03bc<\/jats:italic>m in the non\u2010exudative AMD and 81.76\u00a0\u00b1\u00a03.69\u00a0<jats:italic>\u03bc<\/jats:italic>m in control group (p\u00a0=\u00a00.387), and these values significantly decreased over time, with an average reduction rate of average GC\u2010IPL \u22120.86\u00a0<jats:italic>\u03bc<\/jats:italic>m\/year in the non\u2010exudative AMD group and \u22120.32\u00a0<jats:italic>\u03bc<\/jats:italic>m\/year in the control group. The difference between two groups was statistically significant (p\u00a0&lt;\u00a00.001), and there was also a significant interaction between group and duration in linear mixed models in mean GC\u2010IPL thickness (p\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reduction rate of the GC\u2010IPL thickness was greater in non\u2010exudative AMD eyes, even at relatively early stages of the disease. Physicians should maintain awareness of the presence of non\u2010exudative AMD in various cases of ophthalmic diseases where GC\u2010IPL thickness evaluation is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14784","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T13:59:42Z","timestamp":1612879182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal changes in the ganglion cell\u2010inner plexiform layer thickness of age\u2010related macular degeneration"],"prefix":"10.1111","volume":"99","author":[{"given":"Ju Mi","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Chungnam National University College of Medicine Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Konyang University college of 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