{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:05:33Z","timestamp":1793675133655,"version":"4.5.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Serum eye drops (SEDs) are used to treat a variety of ocular surface defects. Serum eye drops (SEDs) are normally produced from the patient\u2019s blood. However, not all patients can donate sufficient or suitable blood, and logistics can be challenging. Allogeneic blood from voluntary blood donors does not have these disadvantages. Our aim was to evaluate whether autologous and allogeneic SEDs have comparable efficacy and tolerability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, double\u2010blind crossover trial, patients with severe dry eyes were randomized to first receive autologous SEDs for one month, followed by one\u2010month washout, before receiving allogeneic SEDs for 1\u2009month; or receive the SED preparations in reverse order. The Ocular Surface Disease Index (OSDI) was the primary endpoint, and various secondary endpoints were determined. A linear mixed model with random intercept for each patient was applied per treatment group to compare the pre\u2010 and postoutcome measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients were enrolled, of whom 15 completed the trial. When autologous SEDs were used, the mean\u2009\u00b1\u2009SD OSDI improved from 62\u2009\u00b1\u200919 to 57\u2009\u00b1\u200918. For allogeneic SEDs, the OSDI changed from 59\u2009\u00b1\u200920 to 56\u2009\u00b1\u200923. The estimated mean difference (95% confidence interval) was \u22124.2 (\u22129.5 to 1.2) for autologous and \u22124.5 (\u22129.8 to 0.9) for allogeneic SEDs (both, not significant). Adverse events were mild and resolved completely.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Autologous and allogeneic SEDs have comparable efficacy and tolerability for use in patients with severe dry eyes. Allogeneic SEDs are therefore an attractive alternative for patients who need SEDs but are clinically or logistically unable to donate blood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14788","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T08:14:01Z","timestamp":1613549641000},"page":"837-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Allogeneic and autologous serum eye drops: a pilot double\u2010blind randomized crossover trial"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-3604","authenticated-orcid":false,"given":"Pieter F.","family":"van der Meer","sequence":"first","affiliation":[{"name":"Department of Product and Process Development Sanquin Blood Bank Amsterdam The Netherlands"},{"name":"Department of Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Department of Haematology Haga Teaching Hospital The Hague The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne K.","family":"Verbakel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ine","family":"Honohan","sequence":"additional","affiliation":[{"name":"Department of Clinical Transfusion Research Sanquin Research Leiden The Netherlands"},{"name":"Clinical Research Office Dijklander Hospital Hoorn The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Lorinser","sequence":"additional","affiliation":[{"name":"Department of Product and Process Development Sanquin Blood Bank Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier M.","family":"Thurlings","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joannes F.M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Laboratory Medical Immunology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"de Korte","sequence":"additional","affiliation":[{"name":"Department of Product and Process Development Sanquin Blood Bank Amsterdam The Netherlands"},{"name":"Department of Blood Cell Research Sanquin Research Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina A.","family":"Eggink","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703079"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180645cd7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270415"},{"key":"e_1_2_5_5_1","first-page":"200","article-title":"Serum eye drops for the treatment of ocular surface diseases: a systematic review and meta\u2010analysis","volume":"17","author":"Franchini M","year":"2019","journal-title":"Blood 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