{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:20:29Z","timestamp":1789633229600,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the impact of intravitreal injections (IVTI) on ocular surface of patients treated with multiple injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, tricentric study conducted in patients treated with unilateral IVTI. An asepsis protocol with povidone\u2010iodine was used for all patients during IVTI. The primary endpoint was the difference between the pre\u2010IVTI Ocular Surface Disease Index (OSDI 1) score and that measured on day one (D1) post\u2010IVTI (OSDI 2). Secondary endpoints were the evaluation of predictive factors for OSDI scores, pain assessment on D1, and the Lacrydiag\u00ae analysis of tears from the injected eye versus contralateral eye before IVTI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and nineteen patients with a mean age of 75.9\u2009\u00b1\u200910\u2009years were included. The mean OSDI2\u2010OSDI1 difference was 19.2\u2009\u00b1\u200920.6 (p\u2009&lt;\u20090.001). The mean noninvasive tear break\u2010up time was 6.41\u2009\u00b1\u20094.59\u2009seconds in the injected eye versus 7.36\u2009\u00b1\u20094.36\u2009seconds in the contralateral eye (p\u2009&lt;\u20090.001). In the multivariate analysis, the factors significantly associated with the OSDI 2 score were the OSDI 1 score (p\u2009&lt;\u20090.001), the pain score on D1 (p\u2009&lt;\u20090.001) the number of instilled glaucoma eye drop (p\u2009=\u20090.01) and a centre effect (centres 2 and 3\n                      <jats:italic>versus<\/jats:italic>\n                      centre 1, p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results confirm the impairment of the ocular surface and quality of life immediately after an IVTI. These results suggest 3 levels of action to improve the immediate tolerance: improving the basal status of the ocular surface, reducing the contact time with povidone\u2010iodine that might be toxic to the surface, and improving immediate post\u2010IVTI treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14797","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T04:53:51Z","timestamp":1616043231000},"page":"877-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A prospective multicentre study of intravitreal injections and ocular surface in 219 patients: IVIS study"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-3650","authenticated-orcid":false,"given":"Sarah","family":"Verrecchia","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"},{"name":"Department of Ophthalmology Croix\u2010Rousse University Hospital Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred\u00e9ric","family":"Chiambaretta","sequence":"additional","affiliation":[{"name":"Gabriel\u2010Montpied University Hospital Center Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Kodjikian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Croix\u2010Rousse University Hospital Hospices Civils de Lyon Lyon France"},{"name":"UMR\u2010CNRS 5510 Mat\u00e9is Villeurbanne Universit\u00e9 Claude Bernard Lyon 1 University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Nakouri","sequence":"additional","affiliation":[{"name":"Gabriel\u2010Montpied University Hospital Center Clermont Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam","family":"El Chehab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Croix\u2010Rousse University Hospital Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Badri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Chudzinski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Levron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayeul","family":"Chaperon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-550X","authenticated-orcid":false,"given":"Emilie","family":"Agard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Pradat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Croix\u2010Rousse University Hospital Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Dot","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Desgenettes Military Hospital Lyon France"},{"name":"French Military Health Service Academy Val de Gr\u00e2ce Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000399"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170271"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2014.11.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1532_18"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000308974"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00409-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2019.11.002"},{"key":"e_1_2_7_10_1","unstructured":"Dry eye T. 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