{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:58:43Z","timestamp":1790632723617,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate choroidal blood flow changes after isometric exercise in patients with chronic central serous chorioretinopathy nontreated or treated with mineralocorticoid receptor antagonists (MRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Foveolar choroidal laser Doppler flowmetry parameters \u2013 velocity (ChVel), volume (ChVol) and blood flow (ChBF) \u2013 of 22 eyes of 22 treated patients, 16 eyes of 16 untreated patients and 19 healthy controls were measured during a squatting test. Treatment consisted in MRA administration (eplerenone 50\u2009mg\/day or spironolactone 50\u2009mg\/day). The experiment comprised three successive periods: 30\u2009seconds of rest, 2\u2009min of continuous squatting exercise, and 150\u2009seconds of recovery. Significance levels were calculated using a generalized estimating equation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the squatting period, nontreated CSCR eyes had a similar change in ChVel (p\u2009=\u20090.8), ChVol (p\u2009=\u20090.8), ChBF (p\u2009=\u20090.5) and resistance to healthy eyes. Treated CSCR eyes exhibited significantly smaller changes in ChVel (\u22120.1\u2009\u00b1\u200911%, p\u2009=\u20090.04) than healthy eyes (6\u2009\u00b1\u20098%). No significant difference was found for ChVol and ChBF between the groups. The increase in ChVol from baseline in the nontreated CSCR group (4.4\u2009\u00b1\u20099%) was lower than that of treated group (6.7%\u00b111%; p\u2009=\u20090.01). Finally, ChBF and ChVel changes in the CSCR groups were not significantly different.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No abnormalities were detected in the changes in ChBF parameters during increased ocular perfusion pressure in nontreated CSCR patients compared with controls. MRA treatment in CSCR patients induced a significant reduction in ChBVel and an increase in ChBVol in response to isometric exercise, suggesting that MRA exerts effects on choroidal vascular changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14809","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T02:20:12Z","timestamp":1614651612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of eplerenone on choroidal blood flow changes during isometric exercise in patients with chronic central serous chorioretinopathy"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9539-3315","authenticated-orcid":false,"given":"Mathilde","family":"Gallice","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Grenoble Alpes University Grenoble 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