{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:52:04Z","timestamp":1792547524011,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:00:00Z","timestamp":1613865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Retinopathy of prematurity (ROP), one of the leading causes of childhood blindness, is a complex condition in which various antenatal and neonatal factors participate at different stages of the disease. This meta\u2010analysis was conducted to investigate whether pregnancy\u2010induced hypertension (PIH) was associated with ROP by summarizing all available evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Web of Science, EBSCO and SCOPUS databases were searched for all relevant studies published from inception to April 2020. Studies investigating the association between PIH and ROP were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 29 studies were finally included for the meta\u2010analysis after study selection. The results showed there are both no significant association between PIH and the occurrence of ROP in case\u2013control studies (OR 0.91, 95%CI 0.59 to 1.40, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200981%, p\u2009=\u20090.67) and cohort studies (OR 1.32, 95%CI 0.89 to 1.98, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200993%, p\u2009=\u20090.17). The conclusion was same between pre\u2010eclampsia and ROP (OR 0.82, 95%CI: 0.50 to 1.35, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200983%, p\u2009=\u20090.43 in case\u2013control studies and OR 1.70, 95%CI: 0.82 to 3.50, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200995%, p\u2009=\u20090.15 in cohort studies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, this meta\u2010analysis did not reveal a consistent result, the conclusion remains inconclusive, and further studies will be needed to come to a conclusion for the effect of maternal PIH on ROP and foster a better understanding of the prevention of ROP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14827","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T16:10:47Z","timestamp":1613923847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pregnancy\u2010induced hypertension and retinopathy of prematurity: a meta\u2010analysis"],"prefix":"10.1111","volume":"99","author":[{"given":"Ge","family":"Ge","sequence":"first","affiliation":[{"name":"Macular Disease Research Laboratory Department of Ophthalmology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Macular Disease Research Laboratory Department of Ophthalmology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-4843","authenticated-orcid":false,"given":"Meixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Macular Disease Research Laboratory Department of Ophthalmology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-301411"},{"key":"e_1_2_5_3_1","first-page":"158","article-title":"Premat\u00fcre retinopatisi geli\u015fim sikli\u011fi ve etki eden risk fakt\u00f6rlerinin de\u011ferlendirilmesi","volume":"10","author":"Babayi\u011fit A","year":"2014","journal-title":"Bak\u0131rk\u00f6y T\u0131p Dergisi"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.2524"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.5472\/marumj.299376"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.02.021"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903184173"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30732"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.154294"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2015.04.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0416-6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.08.051"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3898"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.52"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1407-127"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.133"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7418.760"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02830827"},{"key":"e_1_2_5_20_1","first-page":"469","article-title":"Pregnant women serum concentrations of Igf\u20101 and IGFBP 1 with neonatal birth weight the relevance of research","volume":"19","author":"Han Y","year":"2013","journal-title":"Guide China Med"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1586109"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101113998"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_5_24_1","volume-title":"Cochrane handbook for systematic reviews of interventions. 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