{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:40:47Z","timestamp":1779154847347,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T00:00:00Z","timestamp":1615680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effect of immunosuppressive therapy on blood flow and waveform parameters in the choroid and optic nerve head (ONH) in patients with initial\u2010onset acute uveitis associated with Vogt\u2013Koyanagi\u2013Harada (VKH) disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, 18 patients (36 eyes) were studied. Laser speckle flowgraphy was performed at baseline and at 4\u2009weeks, 8\u2009weeks and 12\u2009weeks after treatment. We analysed longitudinal changes in mean blur rate (MBR), blow\u2010out time, blow\u2010out score (BOS), acceleration time index (ATI), flow acceleration index (FAI), resistivity index (RI) and blood flow fluctuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After immunosuppressive therapy, MBR, representing blood flow velocity, in the choroid and ONH significantly increased at each post\u2010treatment time point compared to baseline values. Among the analysed pulse waveform parameters, BOS significantly increased, while RI and fluctuation significantly decreased. Increased BOS and decreased RI indicate decreased vascular resistance following treatment. There was a strong negative correlation between BOS and RI. Additionally, FAI increased in the choroid and ATI increased in ONH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunosuppressive therapy in the acute uveitic phase of VKH disease improved inflammation\u2010related impairment in choroidal and ONH blood flow.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14842","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T04:24:35Z","timestamp":1615782275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of immunosuppressive therapy on ocular blood flow in initial\u2010onset acute uveitis associated with Vogt\u2013Koyanagi\u2013Harada disease"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-8617","authenticated-orcid":false,"given":"Ahmed M.","family":"Abu El\u2010Asrar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology College of Medicine 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