{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:51:52Z","timestamp":1787061112945,"version":"build-2736575974"},"reference-count":124,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ocular neovascular diseases, such as proliferative diabetic retinopathy, retinopathy of prematurity and neovascular age\u2010related macular degeneration, are the leading causes of visual impairment worldwide. The hypoxia\u2010inducible factors and vascular endothelial growth factors are key molecular promoters of ocular neovascularization. Moreover, the role of microRNAs as regulators of angiogenesis has been expanding, particularly hypoxia\u2010associated microRNA; hypoxamiRs. This review provides a summary of hypoxamiRs that directly and specifically target\n                    <jats:italic>HIF1A<\/jats:italic>\n                    and\n                    <jats:italic>VEGF<\/jats:italic>\n                    mRNAs, thus critically involved in the regulation of ocular neovascular pathologies. The discussed microRNAs highlight putative diagnostic markers and therapeutic agents in choroidal and retinal angiogenic diseases, including proliferative diabetic retinopathy, retinopathy of prematurity and neovascular age\u2010related macular degeneration.\n                  <\/jats:p>","DOI":"10.1111\/aos.14845","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T08:45:20Z","timestamp":1615970720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["MicroRNAs and the HIF\/VEGF axis in ocular neovascular diseases"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8160-3273","authenticated-orcid":false,"given":"Flavia","family":"Plastino","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences Division of Eye and Vision St. Erik Eye Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5836-8575","authenticated-orcid":false,"given":"Noemi Anna","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Division of Eye and Vision St. Erik Eye Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-2376","authenticated-orcid":false,"given":"Helder","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Division of Eye and Vision St. Erik Eye Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123846"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16476"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2006.01.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.07.031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_6_7_1","first-page":"124","article-title":"Retinopathy of prematurity","volume":"78","author":"Bashinsky AL","year":"2017","journal-title":"N C Med J"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180235"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.08.014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-016-0234-z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.136"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5167604"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066373"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.7135204"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.6.11006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200108000-00002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2662"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095665"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11080868"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.24.10211"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.0437"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.12.037"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218282"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374203-2.00136-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014742"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.109876"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00507-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2384-2-21"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0021-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.07.022"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04482"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25009"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05182-9"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107461"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00431-7"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.09.012"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.11.007"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0893-x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.893068"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11993"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2012.12.155"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21231"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000116"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.7987"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062961"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.111583"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160662"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190332597"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.027029"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.927801"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00801-8"},{"key":"e_1_2_6_52_1","first-page":"673","article-title":"Characterization of cells from patient\u2010derived fibrovascular membranes in proliferative diabetic retinopathy","volume":"21","author":"Kim LA","year":"2015","journal-title":"Mol Vis"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1644"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2007.10.014"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01395-06"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01283.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.991402"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068592"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf476"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf476"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600385"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504017X14847395834985"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.034"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.08.039"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090599"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.10.001"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11658-012-0037-0"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.041"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122217"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03422-9"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.053"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/20459"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1557"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8280"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2521"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2016.11.012"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.10.018"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500008112"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200406000-00006"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.3.241"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.03.030"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-012369"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2015.10"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-016-0051-x"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0014"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2005.04.001"},{"key":"e_1_2_6_88_1","first-page":"1175","article-title":"MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity","volume":"12","author":"Ryan DG","year":"2006","journal-title":"Mol Vis"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.36.22642"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.014"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00759-1"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.11.001"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.4072007cm8"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011165"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v5.i1.35"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.22336\/rjo.2019.4"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.104"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1133-3"},{"key":"e_1_2_6_99_1","first-page":"83","article-title":"MicroRNAs: processing, maturation, target recognition and regulatory functions","volume":"3","author":"Shukla GC","year":"2011","journal-title":"Mol Cell Pharmacol"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54056"},{"key":"e_1_2_6_101_1","first-page":"455","article-title":"Vascular endothelial growth factor (VEGF)\u2010key factor in normal and pathological angiogenesis","volume":"59","author":"Stanca Melincovici C","year":"2018","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-0976-7"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42546"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2017.1312228"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.20"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2855-1"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.2174\/13894501113149990015"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5510"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.3.1230"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060895"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-016-0496-2"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2009.04.002"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5993"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.12"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701476"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1478"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v4.i6.290"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12329"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01363"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1158803"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211040"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25901"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2017.12.001"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.108"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17417"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T21:54:57Z","timestamp":1705874097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":124,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/aos.14845"],"URL":"https:\/\/doi.org\/10.1111\/aos.14845","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]},"assertion":[{"value":"2020-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}