{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:04:32Z","timestamp":1789160672415,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Wet age\u2010related macular degeneration (AMD) and age\u2010related cataract are often coexisting causes of visual impairment. Yet, the timing of cataract surgery in wet AMD patients is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and eleven eyes of 111 patients with wet AMD underwent cataract surgery at Helsinki University Hospital in Finland during 2014\u20132018. Best\u2010corrected visual acuity and central subfield macular thickness (CSMT) were analysed at the time of wet AMD diagnosis, at the last recording prior to cataract surgery and at the first recording and at 1\u2009year after surgery. The cumulative number of antivascular endothelial growth factor (anti\u2010VEGF) injections at surgery, systemic and topical medication and postoperative anti\u2010VEGF burden were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 78.9\u2009\u00b1\u20095.6\u2009years at the time of surgery. Central subfield macular thickness (CSMT) significantly decreased (280.1\u2009\u00b1\u200975.0\u2009\u00b5m preoperatively to 268.6\u2009\u00b1\u200967.6\u2009\u00b5m at the first postoperative recording, p\u2009=\u20090.001, and to 265.9\u2009\u00b1\u200967.9\u2009\u00b5m at 1\u2009year, p\u2009=\u20090.003), visual acuity improved (0.70\u2009\u00b1\u20090.46 logMAR units preoperatively to 0.39\u2009\u00b1\u20090.40 at the first postoperative recording, and to 0.33\u2009\u00b1\u20090.34 at 1\u2009year, p\u2009&lt;\u20090.001 for both) and anti\u2010VEGF treatment intervals lengthened despite the surgery (6.53\u2009\u00b1\u20092.08\u2009weeks prior to surgery to 7.03\u2009\u00b1\u20092.23\u2009weeks at 1\u2009year, p\u2009=\u20090.246, and to 7.05\u2009\u00b1\u20092.57\u2009weeks at the last documented visit, p\u2009=\u20090.035). A CSMT increase of over 30% from the preoperative values was seen in only one case (1 out of 111 eyes, 0.9%). Macular status at surgery, wet AMD subtype, comorbidity of type II diabetes, systemic drugs and topical anti\u2010inflammatory medication were not associated with macular changes nor with treatment intervals after surgery. The cumulative number of anti\u2010VEGF injections correlated neither with CSMT change postoperatively (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.051, p\u2009=\u20090.619) nor with CSMT change at 1\u2009year (<jats:italic>r<\/jats:italic>\u2009=\u20090.091, p\u2009=\u20090.426).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Satisfactory visual outcomes and controlled disease activity were seen in patients with wet AMD undergoing cataract surgery. We found no evidence to support delaying surgery in patients who require it.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14864","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T14:35:21Z","timestamp":1618065321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of cataract surgery on wet age\u2010related macular degeneration activity"],"prefix":"10.1111","volume":"100","author":[{"given":"Petteri","family":"Karesvuo","sequence":"first","affiliation":[{"name":"Helsinki Retina Research Group University of Helsinki Helsinki Finland"},{"name":"Department of Ophthalmology Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-6467","authenticated-orcid":false,"given":"Uri","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University 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