{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:30:47Z","timestamp":1778787047385,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate visual perception problems (VPPs), health\u2010related quality of life (HRQoL) and vision\u2010related quality of life (VRQoL) in young adults with foetal alcohol spectrum disorders (FASD) and to compare the results with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty young adults with FASD (13 female; mean age 23\u2009years) and 29 controls (20 female; mean age 25\u2009years) participated. Five areas of VPPs were assessed by a structured history\u2010taking. In the FASD group, VPPs were investigated both in childhood (mean age 8\u2009years) and in early adulthood in a prospective follow\u2010up. Health\u2010related quality of life (HRQoL) was investigated with the Pediatric Quality of Life Inventory\u2122 (PedsQL) and VRQoL with the 25\u2010item Visual Function Questionnaire (VFQ\u201025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visual perception problems (VPPs) in at least one area were reported by 16\/30 FASD participants (53%) and 1\/29 controls (3%) (p\u2009=\u20090.0001, Fisher\u2019s exact test), with a similar rate in the same individuals in childhood as in early adulthood (8\/27 and 15\/27, respectively p\u2009=\u20090.09, McNemar\u2019s test). PedsQL total score was lower in the FASD group (<jats:italic>n<\/jats:italic>\u2009=\u200920; median: 83; 95% confidence interval (CI) 76\u201388) compared with controls (<jats:italic>n<\/jats:italic>\u2009=\u200929; median: 91; 95% CI 90\u201395; p\u2009=\u20090.0001, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test). VFQ\u201025 subscale general vision indicated lower VRQoL in the young adults with FASD (<jats:italic>n<\/jats:italic>\u2009=\u200919; median: 80; 95% CI 80\u2013100) compared with controls (<jats:italic>n<\/jats:italic>\u2009=\u200929; median: 100; 95% CI 100\u2013100; p\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Young adults with FASD in the present study had more VPPs and worse VRQoL and HRQoL than healthy controls. In the FASD group, VPPs were reported in childhood as well as in early adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14868","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T02:18:06Z","timestamp":1620353886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Visual perception problems and quality of life in young adults with foetal alcohol spectrum disorders"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-4906","authenticated-orcid":false,"given":"Emelie","family":"Gyllencreutz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Region V\u00e4stra G\u00f6taland Skaraborg Hospital Sk\u00f6vde Sweden"},{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7338-0193","authenticated-orcid":false,"given":"Eva","family":"Aring","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Ophthalmology Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdemar","family":"Landgren","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Region V\u00e4stra G\u00f6taland Skaraborg Hospital Sk\u00f6vde Sweden"},{"name":"Gillberg Neuropsychiatry Centre Institute of Neuroscience and Physiology University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Landgren","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre Institute of Neuroscience and Physiology University of Gothenburg Gothenburg Sweden"},{"name":"Department of Pediatrics Region V\u00e4stra G\u00f6taland Skaraborg Hospital Mariestad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-360X","authenticated-orcid":false,"given":"Marita\u00a0Andersson","family":"Gr\u00f6nlund","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Ophthalmology Region V\u00e4stra G\u00f6taland Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20103768.2008.01430.x"},{"key":"e_1_2_5_3_1","unstructured":"AnderssonS(2011):Visual function and ocular morphology in children with surgically treated hydrocephalus. 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