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Penetrating canaloplasty, mainly consisted of tensioning suture\u2010aided Schlemm\u2019s canal dilation and a trabeculectomy, was performed to create a direct communication between the anterior chamber and the Schlemm\u2019s canal. Postoperative IOP, number of glaucoma medications and procedure\u2010related complications were evaluated. Rate of success was defined as IOP\u2009\u2264\u200921, \u226418 and \u226415\u2009mmHg, and a \u226530% IOP reduction without (complete) or with\/without (qualified) IOP\u2010lowering medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 45 eyes had 360\u00b0 catheterization successfully completed. The mean preoperative IOP was 33.9\u2009\u00b1\u200911.7\u2009mmHg (range, 13\u201359.6\u2009mmHg), on 3.2\u2009\u00b1\u20090.8 glaucoma medications (range 2\u20135), which was decreased to 15.4\u2009\u00b1\u20093.7\u2009mmHg (range, 8.6\u201322.5) and 0.2\u2009\u00b1\u20090.6 (range, 0\u20133) medications at 6\u2009months and 14.8\u2009\u00b1\u20093.5\u2009mmHg (range, 9\u201324) and 0.1\u2009\u00b1\u20090.3 (range, 0\u20131) medications at 12\u2009months postoperatively. Complete success at 12\u2009months were achieved in 78.9% (95% CI: 0.65\u20130.93), 71.1% (0.56\u20130.86) and 50.0% (0.33\u20130.67) eyes at IOP\u2009\u2264\u200921, \u226418 and \u226415\u2009mmHg, respectively. Transient IOP elevation (&gt;30\u2009mmHg, 26.7%) and hyphema (11.1%) were the most common early surgical complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Penetrating canaloplasty in PACG appeared to have good\u00a0efficacy and safety profiles in this pilot study. Further studies are justified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14869","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T23:54:18Z","timestamp":1619049258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of bleb\u2010independent penetrating canaloplasty in primary angle\u2010closure glaucoma: one\u2010year results"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-0683","authenticated-orcid":false,"given":"Shaodan","family":"Zhang","sequence":"first","affiliation":[{"name":"The Eye Hospital of Wenzhou Medical University Glaucoma Research Institute of Wenzhou Medical University Zhejiang China"},{"name":"The National Clinical Research Center for Ocular Diseases of China Glaucoma Research Institute of Wenzhou Medical University Wenzhou 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