{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:57:58Z","timestamp":1768921078892,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the association between perinatal risk factors for retinopathy of prematurity (ROP) and central retinal structures of former preterm children seen on optical coherence tomography angiography (OCTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included 40 children with a history of preterm birth and 33 healthy full\u2010term children. We documented their birth weight, gestational age, other significant risk factors for ROP development and presence of ROP. Imaging was performed using swept\u2010source OCTA, and quantitative evaluation was performed. Analytic parameters included the area of foveal avascular zone (FAZ), foveal depth (FD), central subfoveal retinal thickness (CSFT) and capillary density index (CDI) of the deep and superficial capillary plexus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preterm children had significantly smaller FAZ, lower FD and higher CSFT compared to controls (all p\u2009&lt;\u20090.001). Both groups exhibited no differences in total CDI at the superficial (p\u2009=\u20090.969) and deep capillary plexus (p\u2009=\u20090.370). The duration of mechanical ventilation correlated negatively with FAZ and FD but positively with CSFT. The duration of supplemental oxygen treatment correlated negatively with FD. The presence of intraventricular haemorrhage correlated negatively with FAZ and FD but positively with CSFT. Regression analysis found that the duration of mechanical ventilation and the presence of bronchopulmonary dysplasia were associated with lower FD (p\u2009=\u20090.002 and 0.01, respectively) and higher CSFT (p\u2009=\u20090.002 and 0.028, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Central retinal anomalies were identified in former preterm children using OCTA. Macular changes were associated with several risk factors for ROP development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14870","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T08:34:57Z","timestamp":1617870897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Perinatal risk factors associated with central retinal changes in former preterm children on optical coherence tomography angiography"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9854-6241","authenticated-orcid":false,"given":"Alenka","family":"Lavric","sequence":"first","affiliation":[{"name":"Eye Hospital University Medical Centre Ljubljana Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spela","family":"Markelj","sequence":"additional","affiliation":[{"name":"Eye Hospital University Medical Centre Ljubljana Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1815-9947","authenticated-orcid":false,"given":"Jianbin","family":"Ding","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarakshi","family":"Mahajan","sequence":"additional","affiliation":[{"name":"St Joseph Mercy Hospital Oakland MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-5850","authenticated-orcid":false,"given":"Rupesh","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University Singapore"},{"name":"National healthcare Group Eye Institute Tan Tock Seng Hospital Singapore Singapore"},{"name":"Singapore Eye Research Institute Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manca","family":"Tekavcic Pompe","sequence":"additional","affiliation":[{"name":"Eye Hospital University Medical Centre Ljubljana Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002276"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.184747"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002301"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1558"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.07.014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2018.02.004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.09.002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4162-y"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2008.07.010"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001471"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3662-5"},{"key":"e_1_2_5_13_1","first-page":"1217","article-title":"Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis","volume":"41","author":"Hughes S","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"key":"e_1_2_5_16_1","first-page":"e611","article-title":"Choroidal structural changes in preterm children with and without retinopathy of prematurity","volume":"98","author":"Lavric A","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.08.007"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopthalmol.2011.1846"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010020\u20101059\u2010x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)00732-0"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001937"},{"key":"e_1_2_5_22_1","volume-title":"Haemorrhage ischaemia and the perinatal brain","author":"Pape KE","year":"1979"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.01.005"},{"key":"e_1_2_5_24_1","first-page":"2827","article-title":"Astrocytes and blood vessels define the foveal rim during primate retinal development","volume":"41","author":"Provis JM","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310532"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.3616"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507501"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.5877"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.4.822"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.040"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.5052"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301612"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.5185"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:38:31Z","timestamp":1693111111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/aos.14870"],"URL":"https:\/\/doi.org\/10.1111\/aos.14870","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"2020-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}