{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:50:39Z","timestamp":1781070639073,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370998"],"award-info":[{"award-number":["81370998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2019JM\u2010065"],"award-info":[{"award-number":["2019JM\u2010065"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The role of inflammation in retinitis pigmentosa (RP) has been receiving additional attention. However, the association between inflammation and the clinical manifestations and complications of RP is still unclear. This study aimed to evaluate the neutrophil\u2010to\u2010lymphocyte ratio (NLR) of RP complicated with cataract and explore the correlations between the NLR and specific clinical features of RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 79 RP patients complicated with cataract (125 eyes) and 63 age\u2010 and sex\u2010matched patients (63 eyes) with age\u2010related cataract (ARC). Patients\u2019 ocular examination results were collected and complete blood count results were used to calculate NLRs. The correlations between the NLR of RP patients and the parameters of ocular examinations were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NLRs of RP patients with cataracts were significantly higher than those of ARC (1.93\u2009\u00b1\u20090.83 versus 1.65\u2009\u00b1\u20090.59, p\u2009=\u20090.029). The NLRs increased with the severity of posterior subcapsular cataract (PSC), zonular deficiency, poor preoperative best\u2010corrected visual acuity (LogMAR&gt;1), and visual field defects. Analysis of receiver operating characteristic curves suggested that NLR\u2009&gt;\u20091.36 could predict higher degrees (PSC area &gt;3%, &gt;P1) of PSC (p\u2009=\u20090.002, 95% CI, 0.672\u20130.934), and that NLR\u2009&gt;\u20092.12 could predict zonular weakness (p\u2009=\u20090.002, 95% CI, 0.665\u20130.928) in RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The NLRs in RP patients with cataract are not only higher but also associated with several clinical manifestations of RP. The NLR can be a predictive biomarker of higher degrees of PSC (&gt;P1) and zonular weakness in RP before cataract surgery. These results suggest that systemic inflammation may play a role in the pathogenesis of RP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14880","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T08:50:36Z","timestamp":1622796636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Correlation between neutrophil\u2010to\u2010lymphocyte ratio and clinical manifestations and complications of retinitis pigmentosa"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7916-6542","authenticated-orcid":false,"given":"Mengmei","family":"He","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Xijing Hospital Eye Institute of Chinese PLA Fourth Military Medical University Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of 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