{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:13:11Z","timestamp":1792696391875,"version":"4.5.0"},"reference-count":119,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Osteogenesis imperfecta (OI) is a rare inherited heterogeneous connective tissue disorder characterized by bone fragility, low bone mineral density, skeletal deformity and blue sclera. The dominantly inherited forms of OI are predominantly caused by mutations in either the <jats:italic>COL1A1<\/jats:italic> or <jats:italic>COL1A2<\/jats:italic> gene. Collagen type I is one of the major structural proteins of the eyes and therefore is the eye theoretically prone to alterations in OI. The aim of this systematic review was to provide an overview of the known ocular problems reported in OI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search (in PubMed, Embase and Scopus), which included articles from inception to August 2020, was performed in accordance with the PRISMA guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this current review show that almost every component of the eye could be affected in OI. Decreased thickness of the cornea and sclera is an important factor causing eye problems in patients with OI such as blue sclera. Findings that stand out are ruptures, lacerations and other eye problems that occur after minor trauma, as well as complications from standard surgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Alterations in collagen type I affect multiple structural components of the eye. It is recommended that OI patients wear protective glasses against accidental eye trauma. Furthermore, when surgery is required, it should be approached with caution. The prevalence of eye problems in different types of OI is still unknown. Additional research is required to obtain a better understanding of the ocular defects that may occur in OI patients and the underlying pathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14882","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T15:25:06Z","timestamp":1621437906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Ocular characteristics and complications in patients with osteogenesis imperfecta: a systematic review"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8655-0131","authenticated-orcid":false,"given":"Sanne","family":"Treurniet","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section\u00a0Endocrinology Amsterdam Bone Center Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7780-1437","authenticated-orcid":false,"given":"Pia","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section\u00a0Endocrinology Amsterdam Bone Center Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebba A.E.","family":"Ghyczy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-1423","authenticated-orcid":false,"given":"Frank D.","family":"Verbraak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie R.","family":"Curro\u2010 Tafili","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Micha","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Amsterdam Movement Sciences Amsterdam University Medical Center Amsterdam The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bravenboer","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Bone and Calcium Metabolism Lab Amsterdam University Medical Center Amsterdam The\u00a0Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart H.","family":"Ralston","sequence":"additional","affiliation":[{"name":"Centre for Genomic and Experimental Medicine MRC Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"de Vries","sequence":"additional","affiliation":[{"name":"Medical library Vrije Universiteit Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-8345","authenticated-orcid":false,"given":"Annette C.","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Marelise W.","family":"Eekhoff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section\u00a0Endocrinology Amsterdam Bone Center Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38238"},{"key":"e_1_2_5_3_1","first-page":"1","article-title":"Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene causing osteogenesis imperfecta","volume":"2013","author":"Aftab SAS","year":"2013","journal-title":"Endocrinol Diab Metab Case Rep"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001038"},{"key":"e_1_2_5_5_1","first-page":"62","article-title":"Unilateral congenital third nerve palsy associated with osteogenesis imperfecta","volume":"21","author":"Andalib D","year":"2009","journal-title":"Iran J Ophthalmol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcp.2017.0001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1987.34"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e32836032f0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4238\/vol8-1gmr563"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.18.2.124"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118811247"},{"key":"e_1_2_5_12_1","first-page":"95","article-title":"COL1A1 mutation analysis in Lithuanian patients with osteogenesis imperfecta","volume":"44","author":"Benusien\u00e9 E","year":"2003","journal-title":"J Appl Genet"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.63"},{"key":"e_1_2_5_14_1","first-page":"33","article-title":"Osteogenesis imperfecta","volume":"57","author":"Bhadada SK","year":"2009","journal-title":"J Assoc Phys India"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-016-3315-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2015.11.005"},{"key":"e_1_2_5_17_1","first-page":"2375","article-title":"Decreased corneal biomechanical properties in children with osteogenesis imperfecta","volume":"57","author":"Bohnsack BL","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198703000-00018"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439506"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984-0462\/;2017;35;2;00001"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(89)90217-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2018.05.001"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2019.05.004"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030040437014"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v33i1.6692"},{"key":"e_1_2_5_26_1","first-page":"361","article-title":"Algodystrophy in conjunction with van der Hoeve's syndrome","volume":"13","author":"Cherie\u2010Ligniere G","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_27_1","first-page":"100","article-title":"Osteogenesis imperfecta Type I caused by a novel mutation in the start codon of the COL1A1 gene in a Korean family","volume":"45","author":"Cho SY","year":"2015","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200602000-00028"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0414-4"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4029430"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.2.158-a"},{"key":"e_1_2_5_32_1","first-page":"53","article-title":"Osteogenesis imperfecta type 2","volume":"20","author":"Devadas SD","year":"2019","journal-title":"Perinatology"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-009-0729-3"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.7.1062"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2002.00062.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.November.30.5"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000527"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00728-X"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.10.028"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1991.tb19594.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318225418b"},{"key":"e_1_2_5_42_1","first-page":"41","article-title":"Occurrence of unilateral retinoblastoma in three generations of a Louisiana family","volume":"136","author":"Haik GM","year":"1984","journal-title":"J La State Med Soc"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4663-x"},{"key":"e_1_2_5_44_1","first-page":"903","article-title":"Diagnostic image (271). A woman with blue sclerae, brittle bones and hearing loss","volume":"150","author":"Hazenberg AJ","year":"2005","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2241001707"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0b013e3181babe6c"},{"key":"e_1_2_5_47_1","first-page":"807","article-title":"Low ocular rigidity in patients with osteogenesis imperfecta","volume":"20","author":"Kaiser\u2010Kupfer MI","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_48_1","first-page":"807","article-title":"Low ocular rigidity in patients with osteogenesis imperfecta","volume":"20","author":"Kaiser\u2010Kupfer MI","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_49_1","first-page":"191","article-title":"Correlation of ocular rigidity and blue sclerae in Osteogenesis Imperfecta","volume":"104","author":"Kaiser\u2010Kupfer MI","year":"1985","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_5_50_1","first-page":"191","article-title":"Correlation of ocular rigidity and blue sclerae in osteogenesis imperfecta","volume":"104","author":"Kaiser\u2010Kupfer MI","year":"1985","journal-title":"Trans Ophthalmol Soc UK"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182a9b1ac"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199303000-00013"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002345"},{"key":"e_1_2_5_54_1","first-page":"28","article-title":"Family with mild form of osteogenesis imperfecta with recurrent fractures due to novel mutation of COL1A1","volume":"77","author":"Kimura M","year":"2019","journal-title":"J Tokyo Med Univ"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13242"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S58087"},{"key":"e_1_2_5_57_1","first-page":"291","article-title":"Topographic and refractive findings in osteogenesis imperfecta","volume":"33","author":"Koyun I\u00d6","year":"2018","journal-title":"Medeniyet Med J"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051322"},{"key":"e_1_2_5_59_1","first-page":"567","article-title":"Corneal cross\u2010linking in a child with osteogenesis imperfecta syndrome and keratoconus","volume":"10","author":"Kwitko S","year":"2017","journal-title":"Aust Med J"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.12.015"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00209.x"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100617"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391405"},{"key":"e_1_2_5_64_1","first-page":"133","article-title":"Clinical features of taiwanese patients with osteogenesis imperfecta","volume":"98","author":"Lin HY","year":"2009","journal-title":"Mol Genet Metab"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.81"},{"key":"e_1_2_5_66_1","first-page":"360","article-title":"A novel COL1A1 nonsense mutation causing osteogenesis imperfecta in a Chinese family","volume":"13","author":"Liu W","year":"2007","journal-title":"Mol Vis"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4143-8"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000266"},{"key":"e_1_2_5_69_1","first-page":"30","article-title":"Dental manifestations of osteogenesis imperfecta and abnormalities of collagen I metabolism","volume":"18","author":"Lund A","year":"1998","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19940701-17"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001764"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-019-0373-x"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.52"},{"key":"e_1_2_5_74_1","first-page":"137","article-title":"Osteogenesis imperfecta","volume":"14","author":"Marion MS","year":"1993","journal-title":"Am J Otolaryngol Head Neck Med Surg"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.77.8.515"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-016-0495-y"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0000000000000201"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-009-0011-x"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-4328(00)00041-X"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcy060"},{"key":"e_1_2_5_81_1","first-page":"367","article-title":"Current and emerging treatments for the management of osteogenesis imperfecta. Journal of","volume":"6","author":"Monti E","year":"2010","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219169"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110853"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200303000-00017"},{"key":"e_1_2_5_85_1","unstructured":"NHLBIStudy quality assessment tools."},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1302\/1863-2548.13.180190"},{"key":"e_1_2_5_87_1","first-page":"100","article-title":"Novel COL1A1 gene mutation (R1026X) of type I osteogenesis imperfecta: A first case report","volume":"96","author":"Niramitmahapanya S","year":"2013","journal-title":"J Med Assoc Thailand"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810500228993"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2016.01.001"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.20.3.203"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10519.x"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275682"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20070901-11"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-015-0034-2"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.242"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1653"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.95882"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700265"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2014.07.166"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-006-9012-y"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-016-0056-4"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320450207"},{"key":"e_1_2_5_103_1","first-page":"113","article-title":"Clinical variability in osteogenesis imperfecta\u2010variable expressivity or genetic heterogeneity","volume":"15","author":"Sillence DO","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.101"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801651"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.6.358"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209309061964"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2020.103896"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0b013e31817d37aa"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332228"},{"key":"e_1_2_5_111_1","first-page":"A4585","article-title":"Osteogenesis imperfecta: klinische en genetische heterogeniteit","volume":"156","author":"Van Dijk FS","year":"2012","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_5_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36545"},{"key":"e_1_2_5_113_1","first-page":"1174","article-title":"Osteogenesis imperfecta and primary open angle glaucoma: genotypic analysis of a new phenotypic association","volume":"20","author":"Wallace DJ","year":"2014","journal-title":"Mol Vis"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33909"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(03)00212-4"},{"key":"e_1_2_5_116_1","first-page":"975","article-title":"Distinct biochemical phenotypes predict clinical severity in nonlethal variants of osteogenesis imperfecta","volume":"46","author":"Wenstrup RJ","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12617"},{"key":"e_1_2_5_118_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5835"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00722"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(88)80031-9"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.14882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.14882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:41:45Z","timestamp":1693111305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.14882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":119,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/aos.14882"],"URL":"https:\/\/doi.org\/10.1111\/aos.14882","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"2020-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}