{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:38:07Z","timestamp":1788446287186,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the changes in optic disc morphology and peripapillary atrophy (PPA) in diabetic children and adults without diabetic retinopathy (DR) or visual impairment (VI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included two groups of subjects. One group included 91 children with type 1 diabetes mellitus (T1DM) and 86 healthy children, and the other group included 444 adults with T2DM and 442 healthy controls. The optic disc parameters including major and minor axis lengths, optic disc ovality (ODO), optic disc tilt, optic disc area and \u03b2\u2010PPA area were analysed in all subjects. Optic disc rotation and the Bergmeister papilla were analysed only in children. Patients with diabetes and healthy controls were compared in each group of the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both groups, patients with diabetes and healthy controls were matched for age, sex and axial length (AL). Among the children, \u03b2\u2010PPA area was significantly smaller in those with diabetes (0.29\u2009\u00b1\u20090.43\u2009mm<jats:sup>2<\/jats:sup>) than in the healthy controls (0.46\u2009\u00b1\u20090.58\u2009mm<jats:sup>2<\/jats:sup>, p\u2009&lt;\u20090.05). Multiple linear regression analysis showed that diagnosis of DM was negatively associated with \u03b2\u2010PPA area. Longer AL and higher body mass index (BMI) were positively associated with \u03b2\u2010PPA area. Among adults, ODO was significantly larger in those with diabetes (1.14\u2009\u00b1\u20090.09) than in healthy controls (1.12\u2009\u00b1\u20090.06, p\u2009&lt;\u20090.05). Multiple linear regression analysis showed that the BMI and DM were potential risk factors affecting ODO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyperglycaemia had different effects on the optic disc in children and adults. Unlike in healthy controls, hyperglycaemia had an impact on the peripapillary tissue in children and on optic disc shape in adults before DR and VI development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14885","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T09:26:30Z","timestamp":1620206790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Optic disc morphology and peripapillary atrophic changes in diabetic children and adults without diabetic retinopathy or visual impairment"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2476-4382","authenticated-orcid":false,"given":"Qiurong","family":"Lin","sequence":"first","affiliation":[{"name":"Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases National Clinical Research Center for Eye Diseases Shanghai Key laboratory of Ocular Fundus Diseases Shanghai General 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