{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:09:57Z","timestamp":1792188597156,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the effect of clinical factors on the development and progression of atrophy and fibrosis in patients with neovascular age\u2010related macular degeneration (nAMD) receiving long\u2010term treatment in the real world.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An ambispective 36\u2010month multicentre study, involving 359 nAMD patients from 17 Spanish hospitals treated according to the Spanish Vitreoretinal Society guidelines, was designed. The influence of demographic and clinical factors, including the presence and location of retinal fluid, on best\u2010corrected visual acuity (BCVA) and progression to atrophy and\/or fibrosis were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 36\u2009months of follow\u2010up and an average of 13.8 anti\u2010VEGF intravitreal injections, the average BCVA gain was +1.5 letters, and atrophy and\/or fibrosis were present in 54.8% of nAMD patients (OR\u2009=\u20098.54, 95% CI\u2009=\u20095.85\u201312.47, compared to baseline). Atrophy was associated with basal intraretinal fluid (IRF) (OR\u2009=\u20091.87, 95% CI\u2009=\u20091.09\u20133.20), whereas basal subretinal fluid (SRF) was associated with a lower rate of atrophy (OR\u2009=\u20090.40, 95% CI\u2009=\u20090.23\u20130.71) and its progression (OR\u2009=\u20090.44, 95% CI\u2009=\u20090.26\u20130.75), leading to a slow progression rate (OR\u2009=\u20090.34, 95% CI\u2009=\u20090.14\u20130.83). Fibrosis development and progression were related to IRF at any visit (p\u2009&lt;\u20090.001). In contrast, 36\u2010month SRF was related to a lower rate of fibrosis (OR\u2009=\u20090.49, 95% CI\u2009=\u20090.29\u20130.81) and its progression (OR\u2009=\u20090.50, 95% CI\u2009=\u20090.31\u20130.81).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atrophy and\/or fibrosis were present in 1 of 2 nAMD patients treated for 3\u2009years. Both, especially fibrosis, lead to vision loss. Subretinal fluid (SRF) was associated with good visual outcomes and lower rates of atrophy and fibrosis, whereas IRF yields worse visual results and a higher risk of atrophy and especially fibrosis in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.14905","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T10:46:17Z","timestamp":1622803577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The role of retinal fluid location in atrophy and fibrosis evolution of patients with neovascular age\u2010related macular degeneration long\u2010term treated in real world"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8815-4757","authenticated-orcid":false,"given":"Sara","family":"Llorente\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Cl\u00ednica Universidad de Navarra Madrid Spain"},{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Thematic Network of Cooperative Health Research in Eye Diseases (Oftared) Health Institute Carlos III Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Thematic Network of Cooperative Health Research in Eye Diseases (Oftared) Health Institute Carlos III Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Navarra Institute for Health Research IdiSNA Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gonz\u00e1lez\u2010Zamora","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bilbao\u2010Malav\u00e9","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Cl\u00ednica Universidad de Navarra Madrid Spain"},{"name":"Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fern\u00e1ndez\u2010Robredo","sequence":"additional","affiliation":[{"name":"Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory Department of Ophthalmology Cl\u00ednica Universidad de Navarra Pamplona Spain"},{"name":"Thematic Network of Cooperative Health Research in Eye Diseases (Oftared) Health Institute Carlos 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