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We therefore assessed the long\u2010term association between dietary intake of BCAA and incident primary open\u2010angle glaucoma (POAG) and POAG subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed biennially participants of the Nurses\u2019 Health Study (NHS; 65\u2009531 women: 1984\u20132016), Health Professionals Follow\u2010up Study (42\u2009254 men: 1986\u20132016) and NHSII (66\u2009904 women; 1991\u20132017). Eligible participants were 40+ years old and reported eye examinations. Repeated validated food frequency questionnaires were used to assess dietary intake of BCAA. Incident cases of POAG and POAG subtypes defined by visual field (VF) loss and untreated intraocular pressure (IOP) were confirmed by medical record review. Multivariable\u2010adjusted relative risks (MVRRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 1946 incident POAG cases. The pooled MVRRs of POAG for the highest quintile (Q5\u2009=\u200917.1\u2009g\/day) versus lowest quintile (Q1\u2009=\u200911.2\u2009g\/day) of total BCAA intake was 0.93 (95% CI, 0.73\u20131.19; p<jats:sub>trend<\/jats:sub>\u2009=\u20090.45; p<jats:sub>heterogeneity by sex<\/jats:sub>\u2009=\u20090.24). For subtypes of POAG defined by IOP level or POAG with only peripheral VF loss, no associations were observed for men or women (p<jats:sub>trend<\/jats:sub>\u2009\u2265\u20090.20); however, for the POAG subtype with early paracentral VF loss, there was a suggestion of an inverse association in women (MVRR<jats:sub>Q5versusQ1<\/jats:sub>\u2009=\u20090.80 [95% CI, 0.57\u20131.12; p<jats:sub>trend<\/jats:sub>\u2009=\u20090.12]) but not in men (MVRR<jats:sub>Q5versusQ1<\/jats:sub>\u2009=\u20091.38 [95% CI, 0.81\u20132.34; p<jats:sub>trend<\/jats:sub>\u2009=\u20090.28; p<jats:sub>heterogeneity by sex<\/jats:sub>\u2009=\u20090.06]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher dietary intake of BCAA was not associated with POAG risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14971","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:36:35Z","timestamp":1625805395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prospective study of dietary intake of branched\u2010chain amino acids and the risk of primary open\u2010angle glaucoma"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-9550","authenticated-orcid":false,"given":"Akiko","family":"Hanyuda","sequence":"first","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Ophthalmology Keio University School of Medicine  Tokyo Japan"},{"name":"Epidemiology and Prevention Group Center for Public Health Sciences National Cancer Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard A.","family":"Rosner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women\u2019s Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Harvard Medical School Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter C.","family":"Willett","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women\u2019s Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tsubota","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Keio University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Pasquale","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women\u2019s Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Ophthalmology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4812-0557","authenticated-orcid":false,"given":"Jae H.","family":"Kang","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Department of Medicine Brigham and Women\u2019s Hospital Harvard Medical School  Boston 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