{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:25:37Z","timestamp":1772079937782,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005809","name":"Hyderabad Eye Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the long\u2010term visual and surgical outcomes, and associated risk factors for poor outcomes in patients with primary congenital glaucoma (PCG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of medical records of children who underwent combined trabeculotomy\u2212trabeculectomy (CTT) without mitomycin\u2010C as the first surgical procedure by a single surgeon between January 1990 and December 2010. Success was defined as intraocular pressure (IOP) &lt;16\u2009mmHg without (complete) or with (qualified) one glaucoma medication. We used the WHO criteria of vision loss to categorize the levels of vision impairment (VI). For purposes of statistical analysis, we randomly chose one eye of patients for bilateral PCG and affected eye in unilateral PCG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 653 consecutive PCG patients (1128 eyes; mean age, 26\u2009months), of whom 475 (73%) underwent simultaneous bilateral CTT. Kaplan\u2010Meier survival analysis revealed 1\u2010, 5\u2010, 10\u2010, 15\u2010, and 19\u2010year complete success rates of 92.6% (<jats:italic>n<\/jats:italic>\u2009=\u2009372), 75.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009173), 55.9% (<jats:italic>n<\/jats:italic>\u2009=\u200972), 44.7% (<jats:italic>n<\/jats:italic>\u2009=\u200919), and 21.6% (<jats:italic>n<\/jats:italic>\u2009=\u20093), respectively. Multivariate analysis revealed independent associations between failure, preoperative corneal clarity, and prior glaucoma surgery. Mean follow\u2010up was 41\u2009\u00b1\u200951\u2009months (range, 6\u2009months to 19\u2009years; median, 1\u2009year). Of the visual acuity (VA) data in the affected eyes obtained at last follow\u2010up (<jats:italic>n<\/jats:italic>\u2009=\u2009333, 51%), seventy\u2010four patients (22%) had VA of \u22656\/12. Of the remaining 259 patients, 18 (7%) had mild VI, 87 (34%) had moderate VI, 58 (22%) had severe VI, and 96 (37%) were blind. No serious complications were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary CTT may be safely employed to control IOP and may provide long\u2010term benefits in PCG patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.14984","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T07:15:09Z","timestamp":1627456509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Combined trabeculotomy\u2212trabeculectomy for primary congenital glaucoma: long\u2010term experience from a tertiary referral centre in a developing nation"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-4060","authenticated-orcid":false,"given":"Anil K.","family":"Mandal","sequence":"first","affiliation":[{"name":"Jasti V Ramanamma Children\u2019s Eye Care Centre L V Prasad Eye Institute Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya K.","family":"Gothwal","sequence":"additional","affiliation":[{"name":"Brien Holden Eye Research Centre \u2013 Patient Reported Outcomes Unit L V Prasad Eye Institute Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Khanna","sequence":"additional","affiliation":[{"name":"Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care L V Prasad Eye Institute Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.047761"},{"key":"e_1_2_5_3_1","first-page":"225","article-title":"Discussion of paper by Quigley HA","volume":"89","author":"Anderson DR","year":"1982","journal-title":"Ophthalmology"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34484-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.41"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.015"},{"key":"e_1_2_5_7_1","first-page":"3","volume-title":"Childhood Glaucoma: The 9th consensus report of the World Glaucoma Association","author":"Beck A","year":"2013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/301725"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19791101-10"},{"key":"e_1_2_5_10_1","first-page":"479","article-title":"Combined trabeculotomy\u2010trabeculectomy as the initial surgical procedure of primary developmental glaucoma [in Spanish]","volume":"83","author":"Compos\u2010Mollo E","year":"2008","journal-title":"Arch Soc Esp Oftalmol"},{"key":"e_1_2_5_11_1","first-page":"545","article-title":"Population\u2010based assessment of childhood blindness in southern India","volume":"116","author":"Dandona L","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.11.025"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.8.608"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(83)90174-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.78.10.745"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.126"},{"key":"e_1_2_5_17_1","first-page":"76","article-title":"Epidemiology and genetics of primary congenital glaucoma in Slovakia. 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