{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:16:58Z","timestamp":1790817418274,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09444"],"award-info":[{"award-number":["18K09444"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate whether the efficacy of anti\u2010vascular endothelial growth factor (VEGF) monotherapy for polypoidal choroidal vasculopathy (PCV) differs between pachychoroid and non\u2010pachychoroid phenotypes in the long term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective longitudinal study included 115 treatment\u2010na\u00efve eyes in 115 consecutive patients with symptomatic PCV who were treated with anti\u2010VEGF monotherapy and were followed up for 5\u2009years. Eligible eyes were assigned to either a pachy\u2010PCV group, with a pachychoroid phenotype, or a non\u2010pachy\u2010PCV group, without a pachychoroid phenotype. Best\u2010corrected visual acuity (BCVA) and other parameters over a 5\u2010year period were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight eyes and 67 eyes were classified into the pachy\u2010PCV and non\u2010pachy\u2010PCV groups respectively. Baseline and 5\u2010year BCVA (logarithm of the minimum angle of resolution) were 0.19\u2009\u00b1\u20090.20 and 0.16\u2009\u00b1\u20090.28 in the pachy\u2010PCV group, respectively, and 0.25\u2009\u00b1\u20090.26 and 0.26\u2009\u00b1\u20090.36 in the non\u2010pachy\u2010PCV group respectively. BCVA did not change significantly in either group (p\u2009=\u20090.18 and 0.08 respectively). BCVA did not differ between the groups at any observation time\u2010point. Subfoveal choroidal thickness (SFCT) at baseline and at 5\u2009years was significantly higher in the pachy\u2010PCV group than in the non\u2010pachy\u2010PCV group (both p\u2009&lt;\u20090.001); however, the mean rate of decrease in SFCT did not differ in either group over the 5\u2010year period (22% vs. 23%, p\u2009=\u20090.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that anti\u2010VEGF monotherapy was similarly effective for pachychoroid\u2010 and non\u2010pachychoroid\u2010phenotype eyes with PCV, for at least 5\u2009years, although further studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15015","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T10:47:32Z","timestamp":1631875652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pachychoroid\u2010phenotype effects on 5\u2010year visual outcomes of anti\u2010VEGF monotherapy in polypoidal choroidal vasculopathy"],"prefix":"10.1111","volume":"100","author":[{"given":"Yuichiro","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine  Kyoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7574-1749","authenticated-orcid":false,"given":"Manabu","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine  Kyoto City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotaro","family":"Ooto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine  Kyoto City 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