{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:51:16Z","timestamp":1769694676635,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009707","name":"Diabetesforbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008564","name":"Norges Blindeforbund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the contribution of retinal vessel density (VD), central retinal vessel diameter and retinal oxygen (O<jats:sub>2<\/jats:sub>) saturation independently of other known risk factors in the development of non\u2010proliferative diabetic retinopathy (NPDR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Macular optical coherence tomography angiography (OCTA), central retinal artery\/vein equivalent diameter (CRAE\/CRVE) measurements and retinal oximetry were performed in a cross\u2010sectional study of 166 eyes from 166 individuals with type 1 diabetes (T1D) aged 14\u201330\u2009years. Multiple logistic regression analysis was used to investigate whether O<jats:sub>2<\/jats:sub> saturation, retinal vessel diameters and vessel density in the deep capillary plexus (VD\u2010DCP) were associated with NPDR, when adjusting for known risk factors. The individuals were allocated to one group without and one group with NPDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple logistic regression analysis showed that age (OR\u2009=\u20091.25, 95% CI: 1.04\u20131.49) and AV\u2010difference in O<jats:sub>2<\/jats:sub> saturation (OR\u2009=\u20090.85, 95% CI 0.77\u20130.93) were significantly associated with NPDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that age and lower AV\u2010O<jats:sub>2<\/jats:sub> saturation difference contribute to explaining the grade of NPDR independently of other well\u2010known risk factors. Reduced delivery of O<jats:sub>2<\/jats:sub> to the retinal tissue is associated with the development of NPDR in young patients with T1D and should be given appropriate weight in the risk stratification at early stages of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15018","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T03:06:53Z","timestamp":1634785613000},"page":"388-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retinal venular oxygen saturation is associated with non\u2010proliferative diabetic retinopathy in young patients with type 1 diabetes"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-5282","authenticated-orcid":false,"given":"Nina C.B.B.","family":"Veiby","sequence":"first","affiliation":[{"name":"Center for Eye Research Department of Ophthalmology Oslo University Hospital  Oslo 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