{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:14:31Z","timestamp":1776417271548,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of our study is to evaluate local tumour control rates, radiation side\u2010effects, visual preservation and disease\u2010free survival (DFS) of uveal melanoma (UM) patients treated with fractionated stereotactic radiotherapy (fSRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of UM patients, who were treated with fSRT (<jats:italic>N<\/jats:italic>\u2009=\u2009189), was performed by the Rotterdam Ocular Melanoma Study group (ROMS), the Netherlands, between 1999 and 2014 with a follow\u2010up of at least 5\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1\u2010, 3\u2010, 5\u2010, 10\u2010 and 15\u2010year local tumour control rates were as follows: 99.4%, 92.8%, 92.2%, 89.3% and 89.3%, respectively. Cataract (67.8%) was the most common side\u2010effect of fSRT followed by retinopathy (35.1%), maculopathy (23.8%), vitreous haemorrhage (20.1%), neovascular glaucoma (NVG) (20.0%) and optic neuropathy (12.4%). Patients with anterior located UMs developed cataract more frequently (p\u2009=\u20090.047, multivariable analysis). By multivariable analysis, significant factors for secondary enucleation were tumour recurrence (p\u2009&lt;\u20090.001) and NVG (p\u2009&lt;\u20090.001). In multivariable analysis, risk factors for a worse DFS were larger UM (p\u2009=\u20090.024) and tumours with subretinal fluid (SRF) at baseline (p\u2009=\u20090.038). The 5\u2010year DFS was 77.0% and the best corrected visual acuity decreased significantly after treatment. After 5\u2009years, 22.0% of patients and after 10\u2009years 17.6% of patients had a visual acuity of \u22640.3 logMAR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractionated stereotactic radiotherapy is a good treatment option for small\u2010, medium\u2010 and large\u2010sized tumours with 5\u2010year local tumour control of 92.2%. After 5\u2009years, 22.0% of the patients had a good vision. Independently of tumour location, the visual acuity decreased significantly after treatment. Overall, the 5\u2010year DFS was 77.0%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15029","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T14:05:24Z","timestamp":1631801124000},"page":"511-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fractionated stereotactic radiotherapy for uveal melanoma: Long\u2010term outcome and control rates"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-9395","authenticated-orcid":false,"given":"Jackelien G. 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