{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:45:50Z","timestamp":1790999150204,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess surgical success and the post\u2010operative development of intraocular pressure between XEN45<jats:sup>\u00ae<\/jats:sup>gelstent, Preserflo<jats:sup>\u00ae<\/jats:sup>MicroShunt and trabeculectomy with mitomycin C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 105 eyes from 105 patients of matched cases with refractory open\u2010angle glaucoma, who underwent surgery between January 2019, and August 2020, were evaluated. Patients underwent either stand\u2010alone XEN gelstent insertion with Mitomycin C, stand\u2010alone Preserflo with Mitomycin C or trabeculectomy with Mitomycin C. The primary outcome was the proportion of complete surgical success at 6\u2009months post\u2010operatively (i.e. intraocular pressure between 5mmHg and 18mmHg, no revision surgery, no loss of light perception and no\u2009post\u2010operative\u2009pharmaceutical antiglaucomatous treatment). The\u2009reduction of intraocular pressure after 6\u2009months, the classes of antiglaucomatous medication used post\u2010operatively, best\u2010corrected visual acuity, spherical refractive errors and astigmatism were assessed as secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 35 eyes in each group.\u2009After 6\u2010month follow\u2010up, complete success was 73.5% [95%\u2010CI: 57.9%\u201389.2%] in the trabeculectomy group, 51.4% [95%\u2010CI: 34.0%\u201368.8%] in the XEN group and 74.2% [95%\u2010CI: 57.9%\u201390.5%] in the Preserflo group (p\u2009=\u20090.08). Regarding secondary outcomes, the reduction of intraocular pressure was 12.1\u2009\u00b1\u20097.9\u2009mmHg in the trabeculectomy group and was thereby 5.8 [95%\u2010CI: 2.2\u20139.6] mmHg greater compared with the XEN group (p\u2009&lt;\u20090.001) and 4.8 [95%\u2010CI: 0.9\u20138.7] mmHg higher than the Preserflo group (p\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No statistically significant differences were\u2009found between trabeculectomy, XEN45<jats:sup>\u00ae<\/jats:sup>gelstent implantation and Preserflo<jats:sup>\u00ae<\/jats:sup>MicroShunt implantation regarding surgical success after 6\u2009months. Yet reduction in intraocular pressure was significantly higher in the trabeculectomy group. However, all three interventions resulted in sufficiently low post\u2010operative intraocular pressure and may\u2009therefore be considered individually for glaucoma treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15042","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T14:38:58Z","timestamp":1633876738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Comparison of subconjunctival microinvasive glaucoma surgery and trabeculectomy"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9560-0524","authenticated-orcid":false,"given":"Felix M.","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Munder","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Muehl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Chronopoulos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Klinikum Frankfurt Hoechst Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0949-4268","authenticated-orcid":false,"given":"Esther M.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.023"},{"key":"e_1_2_5_3_1","first-page":"1941","article-title":"XEN(\u00ae) implant and trabeculectomy medium\u2010term quality of life assessment and comparison of results","volume":"11","author":"Bas\u00edlio AL","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001734"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000368"},{"key":"e_1_2_5_6_1","first-page":"Cd004399","volume-title":"The Cochrane database of systematic reviews","author":"Burr J","year":"2005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-317299"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.07.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.07.023"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.046"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0243-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","unstructured":"KassambaraA(2020):rstatix: Pipe\u2010friendly framework for basic statistical tests. 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