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Various serum and plasma growth factors and inflammatory mediators have been linked to AMD. We were interested in finding out whether systemic levels of EMT\u2010associated markers were altered in the serum of wet AMD patients. Serum biomarkers associated with the various pathological processes of AMD may present an avenue towards identifying and characterizing the birth mechanisms of wet AMD, its progression and severity, paving the way towards the application of precision medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We chose to measure the serum levels of known biomarkers of EMT \u2013 EGF (epidermal growth factor), ET\u20101 (endothelin 1), IL\u20108 (interleukin 8), TGF\u2010\u03b21 and TGF\u2010\u03b22 (transforming growth factor\u2010beta 1 and 2) and VEGF\u2010A (vascular endothelial growth factor A) \u2013 using enzyme\u2010linked immunosorbent assays. We measured them from 71 Finnish wet AMD patients who were receiving intravitreal anti\u2010VEGF\u2010A injection treatments, as well as 64 age\u2010adjusted controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found significantly elevated levels of ET\u20101, IL\u20108 and TGF\u2010\u03b22 in the serums of wet AMD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ET\u20101, IL\u20108 and TGF\u2010\u03b22 appear to be useful serum biomarkers in understanding active wet AMD. However, we cannot conclude that local retinal EMT\u2010processes could be observed from the corresponding systemic serum biomarkers in patients undergoing anti\u2010VEGF\u2010A treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15051","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T16:57:30Z","timestamp":1635267450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Epithelial\u2013mesenchymal transition\u2010related serum markers ET\u20101, IL\u20108 and TGF\u2010\u03b22 are elevated in a Finnish wet age\u2010related macular degeneration cohort"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-4041","authenticated-orcid":false,"given":"Mikko P. 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