{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:42:36Z","timestamp":1774316556712,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 17\/01073"],"award-info":[{"award-number":["PI 17\/01073"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the association between the ganglion cell complex (GCC) thickness at early school\u2010age and prematurity and other neonatal factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study. The sample included very preterm children with gestational age (GA) below 32\u2009weeks or birthweight below 1500\u2009g enrolled in a follow\u2010up program (<jats:italic>n<\/jats:italic>\u2009=\u2009101) and a comparison group of term\u2010born children (<jats:italic>n<\/jats:italic>\u2009=\u200949). Ganglion cell complex (GCC) thickness was measured at 4\u20138\u2009years using high\u2010quality optical coherence tomography (OCT) images. Data on neonatal and postnatal features were extracted from clinical records; analyses included mixed linear models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ganglion cell layer (GCL) and retinal nerve fiber layer (mRNFL) were thicker in term than in preterm born children (2.9\u2009<jats:italic>\u03bc<\/jats:italic>m and 2.4\u2009<jats:italic>\u03bc<\/jats:italic>m respectively, p\u2009&lt;\u20090.001). Within the preterm group, lower GA was associated with a decrease in total GCL (0.7\u2009<jats:italic>\u03bc<\/jats:italic>m per week, p\u2009&lt;\u20090.001). Being small for GA was associated with further thinning in both layers (1.4 and 2.8\u2009<jats:italic>\u00b5<\/jats:italic>m). Postnatal corticosteroids therapy and severe brain lesion were associated with thinning in the total GCL of 6\u2009<jats:italic>\u00b5<\/jats:italic>m (p\u2009&lt;\u20090.001) and 4.1\u2009<jats:italic>\u00b5<\/jats:italic>m (p\u2009=\u20090.002), respectively, and shock was associated with thinning in total mRNFL of 6\u2009<jats:italic>\u00b5<\/jats:italic>m (p\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower GA or birthweight are associated with thinning of GCC layers. When performing an OCT examination at school\u2010age and a decrease in GCC thickness is observed, it may be relevant to ask about a history of prematurity, and further enquire about neonatal shock, postnatal corticosteroids therapy or severe brain lesion that are related to additional decrease in GCC thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15073","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T06:06:10Z","timestamp":1638857170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Retinal ganglion cell complex thickness at school\u2010age, prematurity and neonatal stressors"],"prefix":"10.1111","volume":"100","author":[{"given":"Ana","family":"Ortueta\u2010Olartecoechea","sequence":"first","affiliation":[{"name":"Madrid University Hospital \u201c12 de Octubre\u201d, Department of Ophthalmology  Madrid 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