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For each subject, two study days were scheduled: on one study day, hyperoxia was induced by breathing 100% oxygen whereas on the other study day, hypoxia was induced by breathing a mixture of 88% nitrogen and 12% oxygen. Perfusion density was calculated in the superficial vascular plexus (SVP) and the deep capillary plexus (DCP), using OCT\u2010A before (normal breathing) and during breathing of the gas mixtures. Retinal vessel calibres in major retinal vessels were measured using a dynamic vessel analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 100% oxygen breathing, a significant decrease in DCP perfusion density from 41.7\u2009\u00b1\u20092.4 a.u to 35.6\u2009\u00b1\u20093.1 a.u. (p\u2009&lt;\u20090.001) was observed, which was accompanied by a significant decrease in vessel diameters in major retinal arteries and veins (p\u2009&lt;\u20090.001 each). No significant change in perfusion density in the SVP occurred (p\u2009=\u20090.33). In contrast, during hypoxia, perfusion density in the SVP significantly increased from 34.4\u2009\u00b1\u20093.0 a.u. to 37.1\u2009\u00b1\u20092.2 a.u. (p\u2009&lt;\u20090.001), while it remained stable in the DCP (p\u2009=\u20090.25). A significant increase in retinal vessel diameters was found (p\u2009&lt;\u20090.01). Systemic oxygen saturation correlated negatively with perfusion density in the SVP and the DCP and retinal vessel diameters (p\u2009&lt;\u20090.005 each).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that systemic hyperoxia induces a significant decrease in vessel density in the DCP, while hypoxia leads to increased vessel density limited to the SVP. These results indicate that the retinal circulation shows the ability to adapt its blood flow to metabolic changes with high local resolution dependent on the capillary plexus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15077","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:07:14Z","timestamp":1639030034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of hyperoxia and hypoxia on retinal vascular parameters assessed with optical coherence tomography angiography"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-1359","authenticated-orcid":false,"given":"Nikolaus","family":"Hommer","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Medical University of Vienna  Vienna 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