{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:38:24Z","timestamp":1794019104395,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Primary congenital glaucoma (PCG) is a form of childhood glaucoma caused by maldevelopment of the anterior chamber. Disease severity differs greatly amongst patients. Ultrasound biomicroscopy (UBM) is a non\u2010invasive technique that can visualize the anterior segment in infants <jats:italic>in\u00a0vivo<\/jats:italic>. The purpose of this narrative review is to make an overview of the UBM data in PCG and study the applicability of UBM in characterizing the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online search was performed on PubMed in December 2020. After a critical appraisal of the included articles, study and patient characteristics were summarized. The UBM measurements of the anterior segment in PCG of the different studies were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies were included in this review. All were cross\u2010sectional prospective studies. A total of 221 PCG eyes were examined. PCG eyes showed a larger trabecular iris angle, decreased iris thickness, narrower or absent Schlemm\u2019s canal and an increased zonular length compared to controls. Abnormal tissue membrane covering the trabecular meshwork and abnormal insertion of the iris and ciliary process were frequently found. The success rate of glaucoma surgery depended on the severity of anterior segment malformations found with UBM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malformations of the anterior segment in PCG can be demonstrated by UBM <jats:italic>in\u00a0vivo<\/jats:italic>. This imaging can help to characterize disease severity and might support surgical treatment decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15082","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T05:04:52Z","timestamp":1640235892000},"page":"605-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Ultrasound biomicroscopy of the anterior segment in patients with primary congenital glaucoma: a review of the literature"],"prefix":"10.1111","volume":"100","author":[{"given":"Robin","family":"Janssens","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center location VUmc  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-478X","authenticated-orcid":false,"given":"Laurentius J.","family":"van Rijn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center location VUmc  Amsterdam The Netherlands"},{"name":"Department of Ophthalmology OLVG Hospital  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrien A.","family":"Eggink","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-6568","authenticated-orcid":false,"given":"Nomdo M.","family":"Jansonius","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-8860","authenticated-orcid":false,"given":"Sarah F.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center location VUmc  Amsterdam The Netherlands"},{"name":"Department of Ophthalmology Dijklander Hospital  Hoorn The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.95248"},{"key":"e_1_2_5_3_1","first-page":"458","article-title":"The development of the trabecular meshwork and its abnormality in primary infantile glaucoma","volume":"79","author":"Anderson DR","year":"1981","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(55)92114-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8346981"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.01.021"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(83)90174-1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00075-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176386"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2007.06.014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200406000-00002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040031081030"},{"key":"e_1_2_5_13_1","first-page":"1725","article-title":"Ultrasound biomicroscopy as a diagnostic tool in infants with primary congenital glaucoma","volume":"5","author":"Hussein TR","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.15557\/JoU.2018.0050"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.88.1.5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20070301-05"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.09.026"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2003.00158.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0690-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76159-8"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32298-X"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2012.06.012"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12057"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-018-0882-6"},{"key":"e_1_2_5_25_1","first-page":"297","article-title":"Pathogenesis of congenital glaucoma; gonioscopic and microscopic anatomy","volume":"59","author":"Shaffer RN","year":"1955","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227602"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.08.022"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ijg.0000212293.93292.c9"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.03.011"},{"key":"e_1_2_5_30_1","unstructured":"The Joanna Briggs Institute. (2017)JBI Critical appraisal checklist for case series.https:\/\/joannabriggs.org\/sites\/default\/files\/2019\u201005\/JBI."},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225712.62511.1c"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.15082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:25:46Z","timestamp":1692750346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.15082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/aos.15082"],"URL":"https:\/\/doi.org\/10.1111\/aos.15082","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]},"assertion":[{"value":"2021-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}