{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:11:53Z","timestamp":1769263913315,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the macular pigment optical density (MPOD) and its associations with ocular and systemic parameters and diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The population\u2010based study Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals. As part of ophthalmological and systemic examinations, MPOD was measured by reflectometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Macular pigment optical density (MPOD) data were available for 4889 (82.9%) individuals (mean age:57.8\u2009\u00b1\u200910.1\u2009years;range: 40\u201394). Mean values for MOPD, maximal MOPD, macular pigment (MP) area and MP volume were 0.13\u2009\u00b1\u20090.04\u2009d.u. (density units), 0.36\u2009\u00b1\u20090.09\u2009d.u., 60\u2009791\u2009\u00b1\u200914\u2009826 pixel and 8033\u2009\u00b1\u20092888\u2009d.u.pixel, respectively. A higher MP density was correlated (regression coefficient <jats:italic>r<\/jats:italic>: 0.63) with older age (standardized regression coefficient beta: 0.59; non\u2010standardized regression coefficient B: 0.23; 95% confidence interval (CI): 0.22, 0.23; p\u2009&lt;\u20090.001), female sex (beta: 0.08; B:0.63; 95%CI: 0.44, 0.83; p\u2009&lt;\u20090.001), rural region of habitation (beta: 0.13; B: 1.02; 95%CI: 0.83, 1.22; p\u2009&lt;\u20090.001), lower body mass index (beta: \u22120.04; B: \u22120.03; 95%CI: \u22120.05, 0.01; p\u2009=\u20090.004), lower prevalence of chronic obstructive pulmonary disorder (beta: \u22120.03; B: \u22120.43; 95%CI: \u22120.79, \u22120.08; p\u2009=\u20090.02), higher erythrocyte sedimentation rate (beta: 0.03; B: 0.01; 95%CI: 0.002, 0.02; p\u2009=\u20090.03), lower leukocyte cell count (beta: \u22120.04; B: \u22120.10; 95%CI: \u22120.16, \u22120.03; p\u2009=\u20090.003), thinner temporal parafoveal retinal thickness (beta: \u22120.06; B: \u22120.01;95%CI: \u22120.01, \u22120.003; p\u2009&lt;\u20090.001), thinner central corneal thickness (beta: \u22120.06; B: \u22120.006; 95%CI: \u22120.009, \u22120.004; p\u2009&lt;\u20090.001), higher prevalence of pseudophakia (beta: 0.09;B:2.08; 95%CI: 1.50, 2.65; p\u2009&lt;\u20090.001) and reticular pseudo drusen (RPD) (beta: 0.03; B: 0.56; 95%CI: 0.13, 0.98; p\u2009=\u20090.01) and lower stage of open\u2010angle glaucoma (beta: \u22120.03; B: \u22120.39; 95%CI: \u22120.74, \u22120.04; p\u2009=\u20090. 03). Prevalence (p\u2009=\u20090.44; beta: \u22120.01) and degree (p\u2009=\u20090.70; beta: \u22120.01) of angle\u2010closure glaucoma, prevalence (p\u2009=\u20090.31; beta: 0.01) of age\u2010related macular degeneration (AMD) without RPD and prevalence (p\u2009=\u20090.95; beta: 0.001) of diabetic retinopathy were not significantly associated with the mean MP density in that model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A higher RPD prevalence and lower stage of open\u2010angle glaucoma were ophthalmological disorders associated with a higher MPOD in a multivariable analysis, including parameters of older age, pseudophakia, female sex, rural region, lower body mass index and lower perifoveal retinal thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15131","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T11:46:07Z","timestamp":1648467967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Macular pigment optical density and its determinants in a Russian population: the ural eye and medical study"],"prefix":"10.1111","volume":"100","author":[{"given":"Mukharram M.","family":"Bikbov","sequence":"first","affiliation":[{"name":"Ufa Eye Research Institute  Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur R.","family":"Gilmanshin","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute  Ufa Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinat M.","family":"Zainullin","sequence":"additional","affiliation":[{"name":"Ufa Eye Research Institute  Ufa 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