{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T08:47:00Z","timestamp":1786870020856,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7202229"],"award-info":[{"award-number":["7202229"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop an automated image recognition software for the objective quantification of choroidal vascularity index (CVI) and choroidal thickness (CT) at different choroidal locations on images obtained from enhanced depth imaging optical coherence tomography (EDI\u2010OCT), and to validate its reliability and investigate the difference and correlation between measurements made by manual and software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 390 EDI\u2010OCT scans, captured from 130 eligible emmetropic or myopic subjects, were categorized into four grades in terms of their accessibility to identify the choroidal\u2010scleral interface (CSI) and were further assessed for CT and CVI at five locations (subfoveal, nasal, temporal, superior and inferior) by the newly developed Choroidal Vascularity Index Software (CVIS) and three ophthalmologists. Choroidal parameters acquired from CVIS were evaluated for its reliability and correlation with ocular factors, in comparison to manual measurements. Distribution of difference and correlation coefficient between CVIS and manual measurements were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Choroidal Vascularity Index Software (CVIS) demonstrated excellent intra\u2010session reliability for CT (ICC: 0.992) and CVI (ICC: 0.978) measurements, compared to the relatively lower intra\u2010 and inter\u2010observer reliability of manual measurements. Choroidal Vascularity Index Software (CVIS) and manual assessments had the highest correlation at nasal choroid (CT: <jats:italic>r<\/jats:italic>\u2009=\u20090.829, p\u2009&lt;\u20090.001; CVI: <jats:italic>r<\/jats:italic>\u2009=\u20090.665, p\u2009&lt;\u20090.001). Choroidal parameters identified with CVIS showed stronger correlations with axial length than manual measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This automated software, CVIS, exhibited excellent reliability compared to manual measurements, which are subject to image quality and clinical experience. With its validated clinical relevance, CVIS holds promise to serve as a flexible and robust tool in future vitreoretinal and chorioretinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15152","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T05:24:55Z","timestamp":1649827495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<scp>CVIS<\/scp>: Automated <scp>OCT<\/scp>\u2010scan\u2010based software application for the measurements of choroidal vascularity index and choroidal thickness"],"prefix":"10.1111","volume":"100","author":[{"given":"Jiarui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Peking University Third Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Restoration of Damaged Ocular Nerve  Beijing 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