{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:21:03Z","timestamp":1789474863747,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To map the morphology of the retina and optic disc in adolescents with surgically treated hydrocephalus (HC) in infancy and to compare the results with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 26 adolescents (16 male, mean age 15\u2009years) with HC and 31 sex\u2010 and aged\u2010matched controls. The following optical coherence tomography (OCT) parameters were obtained: macular retinal thickness (MRT) and volume (MRV), thickness of the macular and peripapillary retinal nerve fibre layer (ppRNFL), and area of the optic disc, cup and rim.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MRT was thinner amongst those with HC compared with controls (right eye (RE) 262.2\u2009\u00b1\u200915.3 and 275.8\u2009\u00b1\u200915.1\u2009\u03bcm; p\u2009=\u20090.0051), and the MRV was smaller (RE 7.37\u2009\u00b1\u20090.36 and 7.83\u2009\u00b1\u20090.35\u2009mm<jats:sup>3<\/jats:sup>; p\u2009=\u20090.0002). The HC group showed a thinner ppRNFL (RE 88.3\u2009\u00b1\u200914.9 and 103.5\u2009\u00b1\u20098.1\u2009\u03bcm; p\u2009=\u20090.0002) but a thicker central macular RNFL (RE 11.6\u2009\u00b1\u200910.4 and 2.07\u2009\u00b1\u20093.00\u2009\u03bcm; p\u2009=\u2009&lt;0.0001) and foveal minimum (RE 211.1\u2009\u00b1\u200932.0 and 186.3\u2009\u00b1\u200915.9\u2009\u03bcm; p\u2009=\u20090.0013). Optic disc variables showed no difference between groups. Correlations were found in the HC group between best corrected visual acuity (expressed in logMAR) and ppRNFL (RE r\u2009=\u2009\u22120.56, p\u2009=\u20090.018), and disc area (RE r\u2009=\u2009\u22120.52, p\u2009=\u20090.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thinner ppRNFL and MRT and smaller MRV were found in adolescents with surgically treated HC in infancy compared with controls. In contrast, the central macular RNFL and foveal minimum were thicker. Further studies are required to evaluate the diagnostic value of OCT to indicate increased intracranial pressure timely and follow\u2010up in individuals with surgically treated HC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15162","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T17:59:21Z","timestamp":1651687161000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thinner peripapillary retinal nerve fibre layer and macular retinal thickness in adolescents with surgically treated hydrocephalus in infancy"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-1885","authenticated-orcid":false,"given":"Rezhna","family":"Taha Najim","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg  Gothenburg 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Gr\u00f6nlund","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Deparment of Ophthalmology Faculty of Medicine and Health, \u00d6rebro University  \u00d6rebro 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