{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T18:51:18Z","timestamp":1775933478483,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:00:00Z","timestamp":1653696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K18103;22K09803"],"award-info":[{"award-number":["21K18103;22K09803"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate potential clinical and multimodal imaging factors in central serous chorioretinopathy (CSC) recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was performed at nine Japanese medical institutions for patients who had experienced an active CSC episode. Demographic data and medical history were reviewed retrospectively. Significant differences in chronic manifestation, leakage site, leakage point number, leakage intensity, choroidal hyperpermeability, central retinal thickness (CRT) and subfoveal choroidal thickness were analysed between the recurrence and non\u2010recurrence groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 538 eyes (538 patients) diagnosed with CSC (402 men, 136 women; mean age: 53.4\u2009\u00b1\u200911.9\u2009years) were enrolled. Among them, 253 eyes (47.0%) developed \u22651 recurrence (follow\u2010up: 15.9\u2009\u00b1\u200913.5\u2009months, range 3\u201386\u2009months). Univariate and multivariate analyses indicated that a history of corticosteroid use (odds ratio [OR], 5.52; 95% confidence interval [CI], 1.39\u201321.92; p\u2009=\u20090.015), bilateral disease (OR, 3.94; 95% CI, 1.47\u201310.6; p\u2009=\u20090.007), chronic manifestations (OR, 7.12; 95% CI, 2.93\u201317.28; p\u2009&lt;\u20090.001), non\u2010intense fluorescein leakage (OR, 3.34; 95% CI, 1.44\u20137.75; p\u2009=\u20090.005) and initial CRT (OR, 0.997; 95% CI, 0.993\u20130.999; p\u2009=\u20090.049) were significantly associated with CSC recurrence. Receiver operating characteristic curves were created, and the area under the curve for the multivariate logistic regression model of these five factors was 0.814.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with CSC who received corticosteroids and had bilateral disease, chronic manifestation,\u2009non\u2010intense fluorescein leakage on fluorescein angiography or a relatively thinner CRT should be closely monitored to identify whether they are at high risk of recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15194","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T08:43:14Z","timestamp":1653727394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A multicentre study of the risk factors associated with recurrence of central serous chorioretinopathy"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-0332","authenticated-orcid":false,"given":"Xiaoyin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Hyogo College of Medicine  Hyogo Japan"},{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-6366","authenticated-orcid":false,"given":"Yuki","family":"Komuku","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hyogo College of Medicine  Hyogo Japan"},{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hyogo College of Medicine  Hyogo Japan"},{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Hozumi","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology, Sumitomo Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-3960","authenticated-orcid":false,"given":"Akiko","family":"Miki","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology Kobe University Graduate School of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Kuwayama","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical Sciences  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Niki","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology Tokushima University  Tokushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology Mie University  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0465-2140","authenticated-orcid":false,"given":"Takamasa","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology Sapporo City General Hospital  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomo","family":"Nishi","sequence":"additional","affiliation":[{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"},{"name":"Department of Ophthalmology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Gomi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hyogo College of Medicine  Hyogo Japan"},{"name":"Japan Clinical Retina Study (JCREST) group  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01739640"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25054"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-009-1212-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000742"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.05.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.72.11.829"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324599"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439188"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00442.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.01.021"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.09.034"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000161880"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.81.11.962"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.11.815"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174153"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01975-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.011"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.02.021"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100865"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2011.650776"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000557"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2017.0144"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.04.011"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.07.026"},{"key":"e_1_2_6_27_1","first-page":"T8\u20101","article-title":"Long\u2010term outcome of half\u2010dose verteporfin photodynamic therapy for the treatment of central serous chorioretinopathy (An American ophthalmological society thesis)","volume":"113","author":"Lai TYY","year":"2015","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000929"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32810-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000837"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200202000-00004"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.01.023"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001729"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S242926"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.12.048"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2012.07.004"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70531-8"},{"key":"e_1_2_6_38_1","first-page":"342","article-title":"Angiographic characteristics of central serous chorioretinopathy in an Egyptian population","volume":"6","author":"Shahin MM","year":"2013","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4003-z"},{"key":"e_1_2_6_40_1","first-page":"1","article-title":"Central serous chorioretinopathy: towards an evidence\u2010based treatment guideline","volume":"73","author":"Rijssen TJ","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7217906"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61427"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2022-000976"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.15194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T05:29:07Z","timestamp":1692595747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.15194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,28]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/aos.15194"],"URL":"https:\/\/doi.org\/10.1111\/aos.15194","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,28]]},"assertion":[{"value":"2022-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}