{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:24:25Z","timestamp":1788200665061,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study compares the 8th edition staging of AJCC for prognosis of eyelid Sebaceous Gland Carcinoma (SGC) patients with respect to the 7th edition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was undertaken over a period of 100\u2009months. Ninety\u2010nine histopathologically proven cases of eyelid SGC available for follow\u2010up were recruited. Patients were staged by both the 7th and 8th editions of AJCC and followed up at six monthly intervals after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 99 eyelid SGC patients recruited, recurrence and orbital invasion developed in 22%, lymph node metastasis in 21% and 4% had distant metastasis and also died. High\u2010risk features include tumour size&gt;20\u2009mm, orbital invasion, exenteration and staging by both the 7th and 8th editions of AJCC. Cox regression analysis revealed that staging by AJCC 8th edition was associated with greater risk for local recurrence (HR 3.01,95% CI\u20101.65\u20135.51%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) lymph node metastasis (HR 8.26, 95% CI 3.96\u201317.19%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and disease\u2010free survival (HR 4.61, 95% CI 2.81\u20137.54). The Kaplan\u2013Meir survival curves of eyelid SGC patients by the 8th edition AJCC staging were also significantly associated with lymph node metastasis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), tumour\u2010related deaths (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and reduced disease\u2010free survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.07). The higher Harrell's values by the 8th edition signify better predictive value for lymph node metastasis and DFS (disease\u2010free survival). The lower AIC values indicate a better monotonicity of gradients for lymph node metastasis, recurrence and DFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Staging by the 8th AJCC edition is, therefore, recommended for eyelid SGC as it gives a better perspective about disease outcome. The orbital extension was the single most important predictor of lymph node metastasis, recurrence and death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15204","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T04:44:11Z","timestamp":1656132251000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eyelid sebaceous gland carcinoma, validation of <scp>AJCC<\/scp> 8th edition T staging\u2010 a retrospective study from North India"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-9616","authenticated-orcid":false,"given":"Seema","family":"Sen","sequence":"first","affiliation":[{"name":"Ocular Pathology Services, Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3803-6899","authenticated-orcid":false,"given":"Mansi","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine &amp; Biotechnology Sanjay Gandhi Post Graduate Institute of Medical Science (SGPGIMS)  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perumal","family":"Jayaraj","sequence":"additional","affiliation":[{"name":"Department of Zoology, Assistant Professor Sri Venkateswara college, University of Delhi  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dr.Bhim Rao Ambedkar Institute Rotary Cancer Hospital All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-9868","authenticated-orcid":false,"given":"Neelam","family":"Pushker","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dr.Bhim Rao Ambedkar Institute Rotary Cancer Hospital All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Ocular Pathology Services, Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep S.","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Dr.Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhanshi","family":"Khandpur","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine &amp; 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