{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:37:04Z","timestamp":1790462224296,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to evaluate the impact of adherence to French coronavirus disease 2019 (COVID 19)\u2010related guidelines for intravitreal injection (IVI) practice on the visual outcomes of patients treated with anti\u2010vascular endothelial growth factor (VEGF) agents for macular diseases during the first lockdown period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Observational multicentre study including all patients from 18 centres with an IVI initially planned during the lockdown. Visual acuity (VA, ETDRS) was recorded at 1 and 4\u00a0months after lockdown. French COVID 19\u2010related guidelines recommended maintaining IVI practice. We defined three groups of patients: A, adherent to guidelines; NA+, non\u2010adherent with delayed IVIs; and NA\u2212, non\u2010adherent without IVIs performed during the lockdown. Risk factors for non\u2010adherence and visual loss were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3020 eyes of 3020 patients, aged 77.8\u00a0\u00b1 11.6\u2009years, 59.8% women, were included. 59.3% were non\u2010adherent(46.7% NA+, 12.6% NA\u2212). A smaller decrease in VA at 4\u00a0months was observed in the A group than the NA+ and NA\u2212 group (\u22120.2\u00a0\u00b1\u00a06.7, \u22120.3\u00a0\u00b1\u00a06.9 and \u22121.5\u00a0\u00b1\u00a06.9, respectively [<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001]). Factors associated with non\u2010adherence were in multivariable analysis, older age, hospital practice, low\u2010density population areas, high viral incidence areas, longer intervals between injection and treat and extent protocol. Factors associated with visual loss at 4\u00a0months in multivariable analysis were, being in the NA\u2212 group, older age, T&amp;E and fixed regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Strict adherence to guidelines was associated with better visual outcome, although most of our patients did not attend as planned. Identification of patients at risk could help in the future in case of a new pandemic lockdown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15206","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T08:04:51Z","timestamp":1656489891000},"page":"91-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>IMPACT<\/scp> study: Impact of adherence to <scp>anti\u2010VEGF<\/scp> intravitreal injections for macular disease during <scp>COVID<\/scp> 19\u2010related confinement in France"],"prefix":"10.1111","volume":"101","author":[{"given":"Victoire","family":"Hurand","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital  Dijon 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