{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:37:33Z","timestamp":1791725853357,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study is to test the hypothesis that greater habitual water intake is associated with lower risk of dry eye disease (DED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 51\u2009551 participants from the population\u2010based Lifelines cohort (mean age\u00a0=\u00a051.2\u2009years) in this cross\u2010sectional association study. DED was assessed using the Women's Health Study (WHS) dry eye questionnaire. Water intake was calculated from food frequency questionnaires. Logistic regressions were used to analyse the relationship between DED and water intake or 24\u2010h urine volume, corrected for age, sex, body mass index, physical activity, smoking status, education, income, 48 comorbidities, and 15 medication groups.<\/jats:p>\n                    <jats:p>The main outcome measure was WHS\u2010defined DED. Highly symptomatic dry eye and clinical diagnosis of DED were secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 9.1% of the population had WHS\u2010defined DED. Higher water intake was associated with increased prevalence of WHS\u2010defined DED (OR: 1.011 per 100\u2009ml\/day, 95% CI: 1.004\u20131.017,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003). After excluding those with a clinical diagnosis, greater water intake was still tied to increased risk of having DED symptoms (OR: 1.010 per 100\u2009ml\/day, 95% CI: 1.006\u20131.015,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Higher 24\u2010h urine volumes were also associated with higher risk of WHS\u2010defined DED (OR: 1.010 per 100\u2009ml\/day, 95% CI: 1.005\u20131.015,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large, population\u2010based study, higher water intake was not tied to reduced risk of DED. Rather, it was associated with a modest increased risk of DED. Interventional studies are needed to fully understand the effect of water intake on DED, but this study found no evidence that greater water intake is beneficial for DED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.15227","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T01:24:00Z","timestamp":1660008240000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between habitual water intake and dry eye disease"],"prefix":"10.1111","volume":"101","author":[{"given":"Long","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2276-1770","authenticated-orcid":false,"given":"Morten Schjerven","family":"Magno","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Oslo University Hospital  Oslo Norway"},{"name":"Department of Medical Biochemistry Oslo University Hospital  Oslo Norway"},{"name":"Department of Ophthalmology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Ophthalmology S\u00f8rlandet Hospital Arendal  Arendal Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor P.","family":"Utheim","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Oslo University Hospital  Oslo Norway"},{"name":"Department of Ophthalmology S\u00f8rlandet Hospital Arendal  Arendal Norway"},{"name":"Department of Ophthalmology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-6568","authenticated-orcid":false,"given":"Nomdo M.","family":"Jansonius","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology King's College London, St Thomas' Hospital  London UK"},{"name":"Department of Twin Research &amp; Genetic Epidemiology King's College London, St Thomas' Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-7399","authenticated-orcid":false,"given":"Jelle","family":"Vehof","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Dutch Dry Eye Clinic  Velp The Netherlands"},{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Ophthalmology Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2007.10719661"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2019.04.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101136"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445959"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2010.1459"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820e7cb6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010015\u20100944\u20108"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.02.038"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2009.111"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2020.14.2.143"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11\u20109094"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.05.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114511004776"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114513004455"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/opth.S201127"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2015.11.002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03\u20100915"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2015.0071"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.060"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051289"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2166\/wh.2007.141"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2007.10719656"},{"key":"e_1_2_6_25_1","first-page":"339","volume-title":"Nederlands Voedingsstoffenbestand 2011","author":"NEVO\u2010tabel R","year":"2011"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/opx.0000000000000129"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S86822"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.93"},{"issue":"1","key":"e_1_2_6_29_1","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield W.N.","year":"1985","journal-title":"Human Nutrition Clinical Nutrition"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu229"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab257"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010007\u20109204\u20104"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.04.001"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.2607"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2020.04.005"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.100252"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12\u201010175"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000026009"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010021\u201000891\u20109"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081866"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010016\u20100153\u20109"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.06.009"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010018\u20100671\u2010z"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181f7f363"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14050513"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.15227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.15227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T09:01:31Z","timestamp":1692522091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.15227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/aos.15227"],"URL":"https:\/\/doi.org\/10.1111\/aos.15227","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"2022-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}