{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:22:50Z","timestamp":1793017370833,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071000"],"award-info":[{"award-number":["82071000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of the study was to evaluate myopia progression and axial elongation after stopping 0.01% atropine eye drops through a 2\u2010year cross\u2010over study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a randomized, double\u2010masked, placebo\u2010controlled, cross\u2010over trial in mainland China. 220 children aged 6\u201312\u2009years with spherical equivalent range of \u22121.00 D to \u22126.00 D in both eyes were enrolled in Phase 1 for 1\u2009year. Children who had completed the first year's follow\u2010up continued in the second phase. In Phase 2, the placebo group was crossed over to the 0.01% atropine group (referred to as the \u2018placebo\u2010atropine group\u2019), and the 0.01% atropine group was crossed over to the placebo group (referred to as the \u2018atropine\u2010placebo group\u2019). All children underwent the examination of cycloplegic refraction and axial length at a 6\u2010month interval. Only data from right eyes were included in analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010three subjects completed 2\u2009years of follow\u2010up. In the first year, the mean myopia progression in atropine\u2010placebo group was 0.21\u2009\u00b1\u20090.08 D slower than that in placebo\u2010atropine group. After cross\u2010over treatment, the mean myopia progression in atropine\u2010placebo group was 0.22\u2009\u00b1\u20090.07D faster than that in placebo\u2010atropine group in the second year. Over 2\u2009years, the mean myopia progression was \u22121.26\u2009\u00b1\u20090.66D and\u2009\u22121.25\u2009\u00b1\u20090.70D in the atropine\u2010placebo and placebo\u2010atropine groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.954).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The difference in myopia progression between atropine\u2010placebo group and placebo\u2010atropine group in Phase 1 was similar to Phase 2 during the cross\u2010over treatment. Through our cross\u2010over trial, the results suggest that there is no rebound effect after using 0.01% atropine eye drops to prevent progression of myopia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.15235","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T03:49:44Z","timestamp":1661312984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Myopia progression after cessation of <scp>low\u2010dose<\/scp> atropine eyedrops treatment: A <scp>two\u2010year<\/scp> randomized, <scp>double\u2010masked<\/scp>, <scp>placebo\u2010controlled<\/scp>, <scp>cross\u2010over<\/scp> trial"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8848-6743","authenticated-orcid":false,"given":"Shifei","family":"Wei","sequence":"first","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital Capital Medical University  Beijing China"},{"name":"Beijing Ophthalmology &amp; 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